Algitrisone Injection 1g (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children over 12 years of age may receive 1 to 2 g (activity) of ceftriaxone once daily via intravenous or intramuscular injection, and in cases of severe illness or susceptibility to moderately sensitive pathogens, the dosage may be increased up to 4 g (activity) once daily. For gonorrhea treatment, a single intramuscular injection of 250 mg (activity) is recommended. For infection prevention before and after surgery, 1 to 2 g (activity) should be administered once 30 to 90 minutes before the surgery.

Child administration

In neonates (within 14 days of birth), 20 to 50 mg (activity) per Kg of body weight should be administered once daily, not exceeding 50 mg (activity) per Kg of body weight. Infants and children (from 15 days to 12 years of age) should receive

This medication should not be used with solutions containing calcium. Mixing or administering calcium-containing medications simultaneously can result in dangerous precipitates. Especially in neonates or premature infants, administering this medication along with calcium-containing solutions can lead to fatal precipitates in the lungs or kidneys, therefore it must not be used. It should not be administered to patients with a history of allergies to this drug or hypersensitivity to cephalosporins or penicillin antibiotics, and to patients allergic to the excipients of this drug. This medication's intramuscular injection should be avoided if there is hypersensitivity to specific local anesthetics such as lidocaine, and it should not be administered intravenously when it contains lidocaine. It should not be used in neonates or premature infants with bilirubin binding disorders, as this medication may increase the risk of bilirubin encephalopathy. Caution is required when administering to patients with severe kidney impairment, those with a history of allergies, elderly patients, and patients in poor health, with necessary dosage adjustments and monitoring. This medication can cause various side effects; common symptoms include eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, liver enzyme abnormalities, headache, dizziness, bronchospasm, loose stools, nausea, vomiting, itching, hematuria, diabetes, phlebitis, pain at the injection site, fever, edema, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B complex deficiency, and ventricular ectopia. Serious allergic reactions or neurological abnormalities may also occur rarely. During administration, it is important to monitor for adverse reactions closely, and if symptoms appear, immediately discontinue administration and seek appropriate treatment. This medication may interact with other drugs, so special caution is necessary, especially when used with diuretics, aminoglycoside antibiotics, vitamin K antagonists, and others. Pregnant or nursing women should carefully decide to use this medication, as it may affect the fetus or neonate, only after consulting with healthcare professionals. The safety of this medication for neonates and premature infants has not been established, so special precautions are required when administering this drug. Elderly patients may be more susceptible to side effects due to decreased physical function, thus careful observation is necessary during administration. Regular blood tests, liver function tests, and kidney function tests should be carried out to detect and manage any abnormalities early. Additionally, this medication should be used as soon as possible after preparation of the injectable solution and stored under proper conditions. Care should be taken while driving or operating machinery as dizziness may occur. This medication should only be administered for the necessary duration to prevent the development of resistant bacteria, and symptomatic treatment should be followed in case of overdose.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or breathing difficulties, asthma attacks, respiratory abnormalities with cough and fever, jaundice indicated by yellowing of skin or eyes, extreme lethargy, sudden and severe headache, lightning-like headache, seizures, consciousness confusion, visual disturbances, paralysis, and urinary changes

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to protect it from exposure to air, ideally at a temperature between 1 to 30 degrees Celsius. This storage method helps maintain the drug's efficacy and safety.

Appearance

Vial containing white to pale yellow powder

Package unit

1 vial × 10 pieces