Cramox Tablet 625 Milligrams (Amoxicillin. Clavulanate Potassium (4:1))

Adult dose

Adults and children aged 12 years or older or weighing 40 kg or more: Amoxicillin/Clavulanate Potassium 1 dose of 250 mg/125 mg, administered orally three times a day every 8 hours. In cases of severe and respiratory infections, it can be increased to 1 dose of 500 mg/125 mg. In cases of renal impairment, adjust according to creatinine clearance, when creatinine clearance is 10 to 30 mL/min, administer 1 dose of Amoxicillin 2.

Child dose

For children aged 12 years or older or weighing 40 kg or more, use the same dosage as adults, for children under 12 years or weighing less than 40 kg, no specific dosage is indicated, but in cases of renal impairment, adjustments may be required.

This medication is a beta-lactam antibiotic belonging to the penicillin class. Therefore, it should not be administered to patients who have had hypersensitivity reactions to this medication or similar class drugs. Patients with viral infections such as infectious mononucleosis or lymphocytic leukemia are at a higher risk of rash and should be monitored closely. Patients who have previously experienced liver dysfunction or jaundice from this medication or penicillin may have a risk of recurrence, so it is better to avoid administration. Patients with poor liver function or moderate to severe renal impairment may have increased drug concentration and should use it cautiously with adjusted dosing intervals. Additionally, patients with allergies, those unable to take orally, elderly patients, and those in poor overall condition should be cautious. When taking this medication, gastrointestinal adverse reactions such as diarrhea, vomiting, and abdominal pain may occur, and in severe cases, a serious condition like pseudomembranous colitis may develop, so if symptoms appear, immediate consultation with a healthcare professional is necessary. Various side effects including liver dysfunction, skin rashes, hypersensitivity reactions, blood abnormalities, and kidney dysfunction have been reported, so if any abnormal symptoms appear, it is essential to stop the medication and inform the hospital. Because this medication can cause anaphylactic shock due to hypersensitivity reactions, patient status should be closely monitored after administration, and emergency preparedness is crucial. To prevent the emergence of antibiotic-resistant bacteria, it is important to administer the medication only for the necessary duration based on susceptibility testing, as long-term use carries a risk of overgrowth of resistant bacteria. It should not be administered during the first three months of pregnancy except in special circumstances, and caution is needed during breastfeeding as it may cause adverse effects in infants. This medication is recommended only for children aged 12 years and older or weighing more than 40 kg, and in the elderly, the risk of side effects is higher due to decreased renal and liver function, thus careful adjustment of dosage and intervals is necessary. Additionally, this medication can interact with other drugs, so if there are concurrent medications, it is essential to inform the healthcare professional and proceed with caution. In case of overdose, gastrointestinal symptoms, renal dysfunction, neurological symptoms, etc. may occur, so administration should be stopped immediately and appropriate treatment must be received. Storage should be in a tightly sealed container to avoid moisture, and it is recommended to store it in a cool and dry place below 25 degrees Celsius. Do not stop taking the medication or change the dosage arbitrarily.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/eye mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory distress with coughing and fever, yellowing of skin or eyes (jaundice), extreme fatigue, liver abnormalities (jaundice), sudden and very severe headaches, lightning-like pain.

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, gastric acidity, soft stools, dry mouth, acute pancreatitis, candidiasis, colitis, blood in stools, itching, erythema multiforme, hematological abnormalities (leukopenia, thrombocytopenia, hemolytic anemia, etc.), mucosal candidiasis, vaginal itching, increased secretion, restlessness, anxiety, behavioral changes, confusion, drowsiness, insomnia, lethargy.

This medication should be stored in a tightly sealed container to avoid moisture, and it is recommended to keep it in a cool, dry place below 25 degrees Celsius. Storing in this manner will help maintain the medication's effectiveness over a longer period.

Appearance

(For domestic use) white or nearly white rectangular film-coated tablets (For export) white or nearly white oval film-coated tablets

Package unit

60 tablets ((4 tablets/Alu-Alu) x 15)