Cramon Duo Syrup [Amoxicillin-Potassium Clavulanate (7:1)]

Adult dose

For recurrent tonsillitis and other upper respiratory infections, lower respiratory infections, urinary infections, and mild to moderate skin and soft tissue infections, amoxicillin/potassium clavulanate is generally administered as 25 mg/3.6 mg per kg of body weight divided into two doses daily. For more severe infections such as otitis media, sinusitis, and severe lower respiratory infections, amoxicillin/potassium clavulanate is generally administered as 45 mg/6.4 mg per kg of body weight daily.

Child dose

The 7:1 syrup is not suitable for children under 2 months of age. This syrup is not suitable for pediatric patients with renal failure.

This drug belongs to the beta-lactam class of antibiotics and is part of the penicillin family. It should not be administered to patients who have had hypersensitivity reactions to its ingredients or to other beta-lactam drugs. Special caution is necessary in patients with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock. Patients with viral infections such as infectious mononucleosis or lymphocytic leukemia may have an increased risk of rash and should avoid this medication. Patients with a history of jaundice or liver dysfunction caused by this drug or penicillin should also avoid use due to the risk of recurrence. Patients with impaired liver function should use with caution, as the drug may place strain on the liver, and those with moderate to severe kidney dysfunction may need to adjust dosing intervals due to elevated drug levels. Patients with allergic tendencies or those prone to bronchial asthma and skin rashes should take special caution when using this medication. Patients who have difficulty swallowing, the elderly, or those in poor general condition may have an increased risk of bleeding due to vitamin K deficiency, which requires careful monitoring. Gastrointestinal symptoms such as diarrhea, abdominal pain, and vomiting may occur, and serious enteritis like pseudomembranous colitis may develop; therefore, if severe diarrhea or abdominal pain occurs, the medication should be stopped immediately. Symptoms of liver dysfunction may occur rarely and are more frequently reported in males over 60 years of age or those on long-term therapy. Skin rashes, itching, or severe reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur, so if these symptoms appear, treatment should be discontinued, and medical advice sought. Hematologic abnormalities, including leukopenia, thrombocytopenia, and anemia may occur infrequently, necessitating regular blood testing during prolonged treatment. Central nervous system symptoms such as headaches, dizziness, and seizures may occur rarely, especially in patients with impaired kidney function or those receiving high doses. Regular kidney function tests should be conducted to monitor for potential deterioration, and if abnormalities are detected, treatment should be stopped immediately. This drug may affect the gut flora, leading to conditions such as candidiasis or oral thrush; if symptoms occur, appropriate treatment should be sought. Vitamin K deficiency leading to bleeding tendencies or symptoms of vitamin B complex deficiency has also been reported infrequently and requires caution. Tooth discoloration may occur very rarely, but proper oral hygiene can prevent it. This medication may interact with other drugs, so patients should inform their doctor or pharmacist of any other medications they are taking. It is advisable to avoid using this medication during pregnancy, especially in the first trimester, and caution is advised for breastfeeding mothers as infants may show abnormal reactions such as diarrhea or skin rashes. Use in children, especially in newborns under 2 months, should be approached with caution as safety has not been established. Elderly patients may experience adverse reactions more easily due to decreased bodily function, necessitating careful adjustment of the dosage and intervals. In cases of overdose, gastrointestinal symptoms, electrolyte imbalances, seizures, or hypersensitivity shock may occur, requiring immediate cessation of the drug and appropriate emergency treatment. This drug should be refrigerated after opening and used within 7 days, shaking well before use to ensure uniformity.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with high fever, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough + fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and severe headaches, lightning headaches, seizures, confusion, visual disturbances, paralysis, urination problems.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This drug should be stored in a tightly sealed container to protect it from air and moisture, and it is important to keep it in a dry place below 25 degrees Celsius. Storing this way helps to maintain the medication's efficacy for a longer time.

Appearance

A syrup prepared by dissolving a white or pale yellow powder.

Package unit

50mL (5.5057g) / bottle, 500mL (55.057g) / bottle