Agamate Jelly (Polystyrene Sulfonate Calcium)

Key information summary

Efficacy & effects

This medication is used to treat hyperkalemia, a condition where the potassium levels in the blood are abnormally high due to acute and chronic renal failure.

Dosage

Typically, adults should take 75-150g (as polystyrenesulfonate calcium, 15-30g) by mouth in divided doses of 2-3 times a day. Dosage may be adjusted appropriately based on symptoms.

Precautions

This drug should not be used in patients with hypercalcemia, hyperparathyroidism, or multiple myeloma. It can increase the calcium levels in these patients, posing risks. It is also advisable not to administer it to patients with sarcoidosis or metastatic cancer, or those with obstructive bowel disease, due to the risk of intestinal perforation. Oral administration should be avoided in neonates less than one month old, and only rectal administration may be possible for neonates with reduced gastrointestinal motility. Caution is advised for patients who frequently experience constipation or have intestinal strictures or gastrointestinal ulcers. This drug may cause side effects such as constipation, nausea, anorexia, and hypokalemia; if any abnormal symptoms occur, consult a physician immediately. If there is severe constipation, persistent abdominal pain, or vomiting, stop administration and seek appropriate treatment. During administration, serum potassium and calcium levels should be monitored regularly; if abnormalities are found, adjustments to dosage or cessation of the drug may be necessary. This drug should be discontinued if serum potassium levels drop too low. There is a risk of aspiration when taken orally, so the patient should take it while standing upright. Additionally, since this drug can reduce the absorption and efficacy of other oral medications, it should be taken at least 3 hours apart from other drugs. Its use is not recommended in patients with reduced gastrointestinal motility. Caution should be exercised when used alongside digitalis or digoxin due to increased risk of toxicity from decreased serum potassium. Co-administration with aluminum, magnesium, or calcium-containing antacids or laxatives may reduce the effect of this drug or lead to systemic alkalosis. The safety for pregnant or breastfeeding women has not been established, so caution is required. Elderly patients may have reduced physiological functions, thus careful dosage adjustments are needed. In the event of overdose, symptoms of hypokalemia and cardiac abnormalities may occur, so inform medical personnel immediately and receive appropriate treatment. When taken orally, there is a risk of gastrointestinal perforation or necrosis, so precautions against constipation are necessary, and rectal administration should be performed without using a sorbitol solution to avoid residues.

Side effects

Intestinal perforation, bowel obstruction

Alternatives / Same-ingredient medications

• Kalimet Acid (Polystyrene Sulfonate Calcium)

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• Cashtan (Polystyrene Sulfonate Calcium)

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• Cashtan Suspension (Polystyrene Sulfonate Calcium)

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• Karimet Granules (Polystyrene Sulfonate Calcium)

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