Parkra Capsule (Cefaclor Hydrate)

Adult dose

As cefaclor hydrate, an oral dose of 250 mg (potency) every 8 hours. In cases of severe infections (such as pneumonia) and infections with low susceptibility, the dose may be doubled. In acute gonococcal urethritis, this drug 3 g may be given concurrently with 1 g of probenecid as a single dose.

Child dose

Administer 20 mg (potency) per Kg body weight divided every 8 hours. For severe infections, otitis media, and infections with low susceptibility, 40 mg (potency) per Kg body weight may be administered daily, with a maximum dosage of 1.

This drug works by binding to specific proteins and inhibiting the synthesis of bacterial cell walls, thus killing bacteria. Prior to using this medication, you must inform if you have previously experienced a severe allergic reaction or shock due to this drug or any cephalosporin antibiotics. Patients with a penicillin allergy or those with a family history of asthma, rashes, or urticaria should use this drug cautiously. Patients with severely impaired kidney function, those who have difficulty swallowing, elderly patients, and those in poor general condition should be monitored closely due to the risk of bleeding from vitamin K deficiency. Patients with a history of gastrointestinal diseases, particularly colitis, should consult healthcare providers immediately if symptoms like abdominal pain or diarrhea occur during the use of this drug. Rarely, this drug may cause severe allergic reactions, skin rashes, blood abnormalities, liver dysfunction, kidney problems, gastrointestinal symptoms, respiratory issues, and central nervous system disturbances. Upon experiencing symptoms, discontinue use immediately and seek appropriate treatment. To prevent the occurrence of resistant bacteria during antibiotic use, sensitivity tests should be conducted, and this medication should be administered only for the minimal necessary duration. This drug may interact with other antibiotics or medications, so inform healthcare providers, particularly if taken with probenecid, nephrotoxic drugs, anticoagulants, or oral contraceptives, as dosage adjustments or additional tests may be necessary. Women who are pregnant or likely to become pregnant should only use this drug if the benefits outweigh the risks, and lactating women should use it cautiously as it may be transferred into breast milk in small amounts. Avoid using this drug in infants under one month old as its safety and efficacy have not been established. Elderly patients may be more susceptible to adverse reactions due to declining physical function, thus dosage and administration intervals should be adjusted, and careful monitoring is necessary. This drug may affect the results of some clinical tests, so inform healthcare providers of its use during examinations.

Serious side effects

Shock, severe allergic reactions (generalized flushing, swelling, dyspnea, angioedema, paresthesia, syncope, hypertension, vasodilation), Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, granulocytopenia, pancytopenia, anemia, thrombocytopenia, aplastic anemia, hemolytic anemia, reversible neutropenia, hepatitis, jaundice, elevated AST, ALT, ALP, liver abnormalities, reversible interstitial nephritis, elevated BUN, serum creatinine.

Mild side effects

• Rash
• itching
• fever
• lymphadenopathy
• arthralgia
• serum sickness-like reaction
• nausea
• vomiting
• diarrhea
• abdominal pain

This medication should be kept in a tightly closed container to protect it from air and moisture. Additionally, store the medicine at room temperature that is not too hot or too cold.

Appearance

White to yellowish colored powder in pink capsule, top and bottom

Package unit

30 capsules/bottle, 100 capsules/bottle