International Cefepime Injection 2 grams

Adult administration

For infections caused by gram-positive bacteria, administer 1~2g per day (dosage) divided into 2~3 intravenous doses. For infections caused by gram-negative bacteria, administer 3~4g per day (dosage) divided into 2~3 doses. For life-threatening infections and infections by moderately susceptible bacteria, the dosage may be increased up to 6g per day. In patients with renal impairment, the dosage and dosing interval should be determined according to the degree of renal impairment.

This drug should not be used in patients with a history of allergy to cephalosporin antibiotics. It should also be avoided in premature infants and neonates. Caution is advised when used in pregnant women during the first three months, patients with poor renal and liver function, those with hemophilia or thrombocytopenia, and patients with gastrointestinal ulcers. Close monitoring is required for patients unable to take orally, those receiving parenteral nutrition, elderly patients, and those in poor general condition due to the potential for vitamin K deficiency. Mild hypersensitivity reactions such as headache, dizziness, and nausea may occur, and rarely serious reactions like skin rash, fever, or severe allergic reactions can occur, necessitating immediate discontinuation and appropriate treatment. Liver function test results may temporarily rise, and temporary leukopenia may occur. In the gastrointestinal system, severe colitis like pseudomembranous colitis may occur, and if abdominal pain or frequent diarrhea develops, treatment should be stopped immediately. Respiratory symptoms such as interstitial pneumonia or eosinophilia may rarely occur, so if fever, cough, or breathing difficulties arise, treatment should be discontinued. Rarely, occurrences of oral inflammation or candidiasis may arise. There may also be rare occurrences of bleeding tendencies due to vitamin K deficiency or symptoms of vitamin B deficiency, so caution is warranted. This medication should only be used for the minimal duration necessary and susceptibility testing should be conducted to prevent resistant bacteria. Adequate history-taking and skin response tests are recommended prior to administration in anticipation of allergic reactions, and emergency preparedness for severe reactions like shock is necessary. Resistance to first-generation cephalosporins is increasing, hence susceptibility test results must be referenced. Caution is needed when used in combination with aminoglycoside antibiotics or other drugs that may affect renal function as they can impair kidney function. Increased observation is required when used with high doses of anticoagulants due to the risk of bleeding. Lactating women should be cautious as a small amount of the drug may be transferred through breast milk.

Serious side effects

Anaphylaxis, severe colitis, shortness of breath, skin rash and high fever, fever, cough, difficulty breathing, liver abnormalities (jaundice symptoms not mentioned)

Mild side effects

• Transient mild headache
• dizziness
• nausea
• skin rash
• fever
• vomiting
• loss of appetite
• glossitis
• stomatitis
• neuritis

This medication should be stored in a sealed container to prevent air or moisture ingress and kept away from direct sunlight, preferably at room temperature. Room temperature typically refers to a temperature range of 15 to 25 degrees Celsius, and it is safe to avoid excessively hot or cold environments.

Appearance

A vial containing a white to pale yellow powder

Package unit

10 vials/box [(1 vial × 10)]