Clarithid Film-Coated Tablets 500 mg (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer this drug 500mg (potency) per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcer: Administer this drug 500mg (potency) 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years, use clarithromycin dry syrup.

This medication should not be used by patients with allergies to certain components. Individuals with a history of hypersensitivity to clarithromycin or similar class antibiotics should also refrain from taking it. Patients on certain medications that may affect the heart should avoid using this drug together as it could be dangerous. Patients with a history of arrhythmias or QT interval prolongation should not take this medication. Patients with severely impaired liver function and women who are pregnant or breastfeeding should not use this medication. Patients with central nervous system infections or those on specific medications should also avoid this drug. Patients with reduced kidney or liver function should use this medication cautiously, and dosage adjustments may be necessary. Elderly patients and those with heart disease should take care when using this drug. Caution is also needed when used with other antibiotics, as there may be cross-resistance or side effects. If an allergic reaction occurs, stop taking it immediately and inform healthcare personnel. This drug can cause serious side effects such as severe skin reactions or allergic purpura, so it should be stopped at the first sign of any unusual symptoms. Gastrointestinal side effects may include abdominal pain, diarrhea, and vomiting, and if severe diarrhea or abdominal pain persists, use should be discontinued. Immediate medical evaluation and treatment are necessary if respiratory or blood abnormalities occur. This drug has many interactions with other medications, which may alter drug concentrations or increase the risk of side effects when used concomitantly, so all medications being taken should be disclosed. Special caution is needed if used with heart disease medications, anticoagulants, certain sedatives, and statin drugs. Pregnant or breastfeeding women should not take this medication or should discontinue breastfeeding if absolutely necessary. The safety and efficacy of this drug in children and the elderly may vary, so it should be taken under the direction of healthcare professionals. Overdosage may result in gastrointestinal disturbances or psychiatric symptoms, so the prescribed dosage should be followed. This medication may have reduced absorption when taken with certain other drugs, so it is essential to follow the exact dosing recommendations.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, bloating, diarrhea, oral mucosal erosion, upper abdominal pain, convulsive forms, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, appetite loss, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, bloody stools, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular or cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular psoriasis, muscle spasms, musculoskeletal rigidity, myopathy, elevated blood urea, nephritis, venous inflammation at the injection site, pain at the injection site, inflammation at the injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain a storage temperature between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablets with a vanilla flavor

Package unit

14 tablets/box[14 tablets(7 tablets/PTP x 2)], 100 tablets/bottle