Clarisse 250 mg (Clarithromycin)

Adult dose

○ Adults: The usual dose is 250mg (potency) of clarithromycin per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. For patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

○ Children 12 years of age or older: Same as adults ○ For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used by patients who are allergic to certain ingredients or have had hypersensitivity reactions to macrolide antibiotics. Patients taking certain medications that may affect heart rhythm or those with a history of heart disease should also avoid this drug. Caution is needed for patients with severely impaired liver or kidney function, as the use of this medication may not be appropriate. It is safest not to take this medication during pregnancy or breastfeeding. If any severe allergic reactions, skin rashes, or breathing difficulties occur during treatment, you should immediately stop taking the medication and consult a healthcare professional. Gastrointestinal symptoms such as abdominal pain, diarrhea, or nausea may occur, and if they persist or worsen, you should inform your doctor. This medication may affect liver function; therefore, if symptoms like jaundice, changes in urine color, or itching appear, you must inform your healthcare provider immediately. Caution is also necessary if kidney function is impaired, and you should consult a doctor if any abnormal symptoms arise. This medication has numerous drug interactions, so please inform your healthcare professional of any other medications you are taking. Particularly, caution is needed when taken with some heart medication, anticoagulants, anticonvulsants, and steroids. Symptoms of central nervous system effects such as dizziness, anxiety, insomnia, or hallucinations may occur during treatment, so you should exercise caution. Long-term or high-dose usage may lead to hearing loss or tinnitus, so if there are signs of such symptoms, please consult a physician. Elderly patients should be more cautious as decreased body function may result in higher drug concentrations during medication use. During treatment, you may experience dizziness or decreased concentration while driving or operating machinery, so caution is advised. In case of overdose, gastrointestinal disorders or psychiatric symptoms may occur; immediate medical attention is required.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbances, loss of appetite, constipation, discoloration of stools, membrane colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, leukopenia, thrombocytopenia, pancytopenia, hemolytic anemia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocyte hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disturbance, hearing loss, paraesthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal stiffness, myopathy, vasodilation, venous inflammation at injection site, pain at injection site, inflammation at injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, urine discoloration, asthma, nasal bleeding, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, elevated serum creatinine, elevated blood urea nitrogen, nephritis, venous inflammation at injection site, pain at injection site, inflammation at injection site, fatigue, fever, asthenia, chest pain, chills, fatigue, changes in mental state, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. By following these storage guidelines, the effectiveness of the drug can be maintained, and it can be used safely.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle