Pyrosin Tablets (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to patients with allergies to certain components. Patients with hypersensitivity to macrolide antibiotics should also refrain from using this medication. Patients with severe irregular heartbeats or significantly impaired liver or kidney function should avoid or use this medication with caution. It is safest for pregnant or breastfeeding women not to take this medication. If taken with certain other medications, it may pose risks to heart rhythm, so it is necessary to consult a physician. This medication is primarily metabolized and excreted by the liver and kidneys, so dosage adjustments may be necessary for patients with liver or kidney diseases. If allergic reactions or severe side effects occur, stop using it immediately and consult a healthcare professional. Long-term use may lead to the development of resistant bacteria, so it should only be taken for the prescribed duration. This medication can cause various side effects, including gastrointestinal disturbances, skin rashes, and neurological abnormalities; it is important to report any abnormal symptoms. There are many potential drug interactions, so notify your doctor of any medications you are taking, and do not add or discontinue any medications without consultation. Special caution is required for the elderly or children, particularly in elderly patients with poor kidney function, who may require dosage adjustments. Clinical tests should regularly monitor liver function, kidney function, and blood status; if abnormalities are found, treatment plans should be adjusted. Overdose may lead to gastrointestinal disturbances or neurological symptoms, so it is important to adhere to prescribed doses and inform health professionals immediately if overdose occurs. This medication contains lactose, so it should not be taken by patients with lactose intolerance.

Shock, anaphylactic symptoms, shortness of breath, seizures, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal ulceration, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, hepatic dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized exanthematous pustulosis, muscle spasms, musculoskeletal rigidity, myopathy, vasodilation, cardiac arrest, atrial fibrillation, electrocardiogram QT prolongation, extrasystole, palpitations, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, rash, sweating, vesicular dermatitis, papulopustular rash, acne, Henoch-Schonlein purpura, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, intravenous site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue

This medication should be stored in a tightly sealed container to prevent contact with air, and the storage temperature should be maintained at room temperature, that is, normal room temperature. This helps preserve the efficacy of the medication and prevent degradation.

Appearance

Yellow oval film-coated tablets with a vanilla flavor

Package unit

30 tablets/bottle, 100 tablets/bottle