Question 1

What are the indications and effects of Clarithid Injection 500 mg (Clarithromycin)?

Accepted Answer

This medication is effective against various bacteria and is used to treat lower respiratory tract infections such as bronchitis and pneumonia, upper respiratory tract infections such as pharyngitis, tonsillitis, and sinusitis, as well as skin and soft tissue infections. It is also effective against specific mycobacterial infections caused by Mycobacterium avium or Mycobacterium intracellulare. In other words, it helps treat various bacterial infections, including respiratory and skin-related infections, improving symptoms of infection in patients.

Question 2

What are the dosage and administration instructions for Clarithid Injection 500 mg (Clarithromycin)?

Accepted Answer

It is preferable to administer this medicine for 2 ∼ 5 days and then switch to an oral formulation.
For adults, administer 500 mg (potency) per dose twice daily by intravenous infusion over at least 60 minutes. This medicine must not be given by bolus injection or intramuscular injection. In patients with renal impairment and a creatinine clearance of 30 mL/min or less, reduce the dose by half (the total treatment period should be within 14 days).

Question 3

What are the side effects of Clarithid Injection 500 mg (Clarithromycin)?

Accepted Answer

Shock, symptoms resembling anaphylaxis, respiratory distress, convulsions, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral candidiasis, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, stool discoloration, membrane colitis, hemorrhagic colitis, blood in stool, fever, cough, shortness of breath, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, anorexia, jaundice, dark urine, itching, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated creatine kinase, increased myoglobin in blood, increased myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, ventricular fibrillation, fatigue, headache, taste alteration, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, soft tissue infection, candidiasis, gastroenteritis, infection, vaginitis, shingles, superficial soft tissue infection, erythema nodosum, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, vasodilation, decreased appetite, insomnia, neuroexcitability, noise-induced dysphoria, confusion state, abnormal dreams, mania, dyskinesia, non-vestibular dizziness, drowsiness, tremor, vestibular dizziness, hearing impairment, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, abdominal bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, liver failure, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, acute generalized pustular psoriasis, muscle cramping, musculoskeletal rigidity, myopathy, nephritis, injection site thrombophlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated blood ALP, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

Question 4

What precautions should be taken when using Clarithid Injection 500 mg (Clarithromycin)?

Accepted Answer

This medication should not be used in certain patients. For example, patients allergic to any component of this medication or those who have had hypersensitivity reactions to macrolide antibiotics should not receive it. Furthermore, it should not be administered to patients taking certain medications that may affect heart rate, those with severe liver dysfunction, or pregnant or breastfeeding women. This medication is metabolized and excreted through the liver and kidneys, so caution is required for patients with liver or kidney function impairment. Special care is needed for elderly patients, those with heart disease, or patients taking other antibiotics. While using this medication, various side effects such as allergic reactions, gastrointestinal problems, skin rashes, liver dysfunction, and kidney function deterioration may occur, so if any unusual symptoms manifest, patients should consult their doctor immediately. Additionally, this medication has a high potential for interactions with various other medications, so patients must inform healthcare professionals of any other medications they are taking. It is safest for pregnant or breastfeeding women not to use this medication, and if unavoidable, breastfeeding should be suspended. The safety and effectiveness of this medication in children, especially in those under 12 years of age, have not been sufficiently studied, so caution is needed. Older adults may require dose adjustments due to increased drug concentration from declining kidney function. During treatment with this medication, regular checks of liver and kidney function, as well as blood tests, are important to confirm any abnormalities. In cases of overdose, gastrointestinal disturbances or psychiatric symptoms may occur, so immediate medical attention should be sought. Lastly, this medication may cause dizziness or confusion when driving or operating machinery, so caution is advised.

Clarithid Injection 500 mg (Clarithromycin)

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Efficacy & effects

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Adult administration

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