Hawon Ceftriaxone Injection 1g (Ceftriaxone Sodium Hydrate)

Adult administration

As ceftriaxone, administer 1–2g (as ceftriaxone) once daily by intravenous or intramuscular injection. In cases of severe illness or infections from moderately susceptible pathogens, the dose may be increased up to 4g (as ceftriaxone) once daily. For gonorrhea treatment, a single intramuscular injection of 250mg (as ceftriaxone) is recommended. To prevent infections in surgeries that are contaminated or at risk of contamination, administer 1–2g (as ceftriaxone) based on the risk of infection 30–90 minutes prior to surgery.

Child administration

In neonates (within 14 days of birth), administer 20–50mg (as ceftriaxone) per Kg of body weight once daily and do not exceed 50mg (as ceftriaxone) per Kg of body weight. There is no need to differentiate between premature and full-term infants during dosing.

This medication should not be mixed with solutions containing calcium or other drugs. In particular, there is a risk of precipitation when this drug comes into contact with calcium in neonates, so it must never be administered together. Patients with allergies to this drug or who have had hypersensitivity reactions to similar classes of antibiotics should not use this medication. Also, administration to premature infants or neonates with bilirubin binding issues can be hazardous. Caution is especially necessary when administering to patients with a history of allergies or reduced kidney function. There may be a risk of vitamin K deficiency, and blood tests and vitamin K supplementation may be necessary. Various side effects such as skin rash, hives, diarrhea, liver function abnormalities, and blood cell reductions can occur with the use of this medication, so it is crucial to report any unusual symptoms immediately. Severe allergic reactions can develop, so patients need to be closely monitored during administration. Pregnant or breastfeeding women should consult a physician before using this medication as its safety is not well established. This drug is generally advised against in neonates and premature infants due to the risk of bilirubin encephalopathy. Elderly patients may experience decreased kidney function and bleeding risks; therefore, dosage adjustments and caution are required. This medication may affect blood test results, particularly yielding false positive results in urine glucose tests. Injection should be done slowly as it can irritate the blood vessels, and the injection site should be carefully monitored. In cases of overdose, there is no specific antidote, and appropriate symptomatic treatment should be given. This medication can cause dizziness when driving or operating machinery, so caution is advised. Drug interactions may occur, so patients should inform their doctors about any other medications they are taking, especially calcium supplements, diuretics, and aminoglycoside antibiotics.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, skin peeling, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanying cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, lightning bolt headaches, seizures, confusion of consciousness, visual disturbances, paralysis, urination difficulties

Mild side effects

Eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, elevated liver enzymes, headache, dizziness, bronchospasm, loose stools, nausea, vomiting, pruritus, hematuria, diabetes, phlebitis, injection site pain, fever, edema, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B deficiency, ventricular ectopic beats, sweating, flushing, palpitations, epistaxis, Clostridium difficile-associated diarrhea, hypotension

This medication should be stored in a sealed container to prevent air and moisture ingress, and the storage temperature should be maintained between 1°C and 30°C at room temperature. Storing it this way helps maintain the drug's efficacy and prevents degradation.

Appearance

White to light yellow crystalline powder filled in vials

Package unit

10 vials/case