Ceftriaxone Sodium Hydrate Injection 1 Gram

Adult administration

For adults and children over 12 years of age, administer 1～2g (potency) of ceftriaxone once daily via intravenous or intramuscular injection. In cases of infections caused by pathogens demonstrating moderate sensitivity, the dosage can be increased to 4g (potency) per day. Intramuscular Injection Method: Dissolve 1g in 3.5mL of 1% hydrochloride lidocaine solution, and inject deep into the gluteal muscle. Intravenous Injection Method: Dissolve 1g in 10mL of sterile water for injection and slowly inject over 2 to 4 minutes.

Child administration

For newborns (up to 14 days old), administer 20～50mg (potency) per kg body weight once daily, not exceeding 50mg (potency) per kg body weight. For infants and children (15 days to 12 years old), the dosage is based on body weight

This medication should not be mixed or administered simultaneously with solutions containing calcium or other drugs. Especially, in newborns, co-administration with calcium can lead to precipitation and serious side effects, so it should never be administered. Patients with hypersensitivity to this drug or with allergies to cephalosporin or penicillin antibiotics, and newborns with bilirubin binding disorders should not use this drug. Administering this drug via intravenous injection, which contains lidocaine, is also prohibited. Patients with a history of drug allergies or those with a family history of allergic constitution should exercise caution when using this drug. Additionally, patients with severely impaired kidney function may require dosage adjustments or changes in dosing intervals. Elderly patients or those in poor general condition may have an increased risk of bleeding related to vitamin K deficiency and should undergo blood tests to confirm their condition and supplement vitamin K if necessary. When administering this drug, various side effects may manifest such as eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, liver dysfunction, headache, dizziness, bronchospasm, nausea, vomiting, itching, hematuria, diabetes, phlebitis, injection site pain, fever, edema, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B deficiency, ventricular extrasystoles, increase in serum creatinine levels, fungal infections of the genital area, sweating, flushing, and palpitations. Rarely, serious allergic reactions, kidney dysfunction, and central nervous system disorders may occur, necessitating careful monitoring of the patient’s condition. This drug should be administered only for the minimum necessary duration after susceptibility testing, and regular monitoring of liver, kidney functions, and blood tests during administration is important. In addition, caution is required when driving or operating machinery during treatment due to the potential for dizziness as a side effect. There may also be interactions with other drugs, particularly when used with diuretics or aminoglycoside antibiotics, warranting careful monitoring of kidney function. Co-administration with calcium-containing solutions is very dangerous and must be avoided. Pregnant or breastfeeding women should carefully consider the benefits and risks as the safety of this drug has not been completely established. Children, especially newborns and premature infants, should avoid using this drug due to the risk of bilirubin encephalopathy, and elderly patients should be cautious due to the likelihood of side effects related to decreased physiological function. Finally, the prepared solution should be used as soon as possible, and storage should be within room temperature for up to 6 hours or refrigerated for up to 24 hours for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, skin peeling, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough + fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination issues

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• elevated liver enzymes
• headache
• dizziness
• bronchospasm
• nausea

This drug should be stored in a tightly sealed container to prevent air or moisture exposure. It is best to maintain storage temperatures between 1 and 30 degrees Celsius (room temperature) to ensure the effectiveness of the medication.

Appearance

(Domestic, Export Type 1) White to light yellow crystalline powder filled in a colorless and transparent vial (Export Type 2) [Main Product] White to light yellow crystalline powder filled in a colorless and transparent vial (Export Type 2) [Attachment

Package unit

1 vial, 10 vials