Dilatrend Tablets 12.5 mg (Carvedilol)

Adult dose

Do not increase the dose or stop taking this drug without a physician's instructions. Essential hypertension Adults For the first 2 days, administer carvedilol 12.5 mg orally once daily, then administer 25 mg orally once daily. The usual dose is 25 mg orally once daily for 2 weeks. If an increase is needed, increase to 25 mg twice daily. The maximum dose per administration is 25 mg, and the maximum daily dose is 50 mg. Elderly patients In some elderly patients, 12.5 mg once daily may be sufficient. However, if the effect is inadequate after 2 weeks of treatment, the dose may be increased. Chronic stable angina For the first 2 days, administer 12.5 mg of this drug twice daily orally, then administer 25 mg twice daily orally. The usual dose is 25 mg twice daily for 2 weeks. If an increase is needed (excluding elderly patients), the dose may be increased to 50 mg twice daily. Congestive heart failure Before starting treatment with this drug, the patient's existing standard therapy (conventional treatment for chronic heart failure with an ACE inhibitor, a diuretic, and usually a digitalis preparation) must be stable. Fluid retention should also be minimized before starting treatment with this drug. In general, the initial dose is 3.125 mg of this drug orally twice daily for 2 weeks. If the patient tolerates this treatment well, increase the dose to 6.25 mg twice daily for 2 weeks, then to 12.5 mg twice daily for 2 weeks, and then to 25 mg twice daily. Increase the dose gradually after administering each dose level for at least 2 weeks, up to the dose tolerated by the patient. The minimum effective dose is 6.25 mg twice daily. The maximum dose is 25 mg twice daily for patients weighing 85 kg or less and 50 mg twice daily for patients weighing more than 85 kg. To control the rate of absorption, it is recommended to take the drug with meals in the morning and evening. Taking it with meals slows absorption and may reduce the incidence of orthostatic hypotension.

This drug should not be administered to certain patients. For example, patients allergic to this drug or its components, those with cardiogenic shock, patients with abnormal cardiac conduction, patients with cor pulmonale, those experiencing ketone acidosis due to diabetes, patients with severely impaired cardiac function, asthma or chronic obstructive pulmonary disease patients, patients with secondary hypertension, Prinzmetal angina patients, acute pulmonary embolism patients, those taking certain medications, patients with severe hypotension, patients with severe liver dysfunction, pregnant or breastfeeding women, patients with peripheral circulatory disorders, patients with vocal cord edema, patients with complications from myocardial infarction, patients with excessive fluid retention, allergic rhinitis patients, and lactose intolerant patients should not take this drug. Additionally, patients with diabetes, those with a history of hypersensitivity or psoriasis due to beta-blockers, patients with hypotension or renal dysfunction, patients with unstable angina, chronic congestive heart failure patients, patients with severe kidney impairment, patients with mild to moderate bradycardia, elderly individuals, patients with acute inflammatory heart disease, patients taking certain drugs in combination, fasting patients, patients with hyperthyroidism, contact lens users, individuals under 18 years of age, and patients with acute myocardial infarction should use caution when administering this drug. When taking this medicine, mild central nervous system symptoms such as dizziness, headache, and fatigue may occur, and rarely, symptoms such as hallucinations or psychosis may arise. Serious adverse reactions such as bradycardia, shock, heart failure, or cardiac arrest may occur in the cardiovascular system, necessitating regular cardiac function tests. There is also a risk of sudden drops in blood pressure or loss of consciousness, so caution is advised. For patients with poor renal function, kidney function may worsen, and in patients with respiratory diseases, airway resistance may increase. Gastrointestinal issues such as nausea, diarrhea, abdominal pain, and vomiting can occur, and skin reactions such as hives, itching, and allergic rashes may appear. Adverse reactions have been reported in various body systems, including the blood, endocrine, and liver, so if any unusual symptoms occur, immediate consultation with healthcare professionals is required. For long-term use of this drug, regular monitoring of heart function, blood pressure, and pulse is necessary, and sudden discontinuation may lead to myocardial infarction or worsening angina, thus it should be gradually reduced under a doctor's guidance. Furthermore, it is crucial to conduct periodic blood pressure and electrocardiogram tests during initial doses or dosage increases. Due to numerous interactions with other drugs, especially antihypertensives, sedatives, antidepressants, calcium channel blockers, antiarrhythmics, insulin, oral hypoglycemics, cyclosporine, and alcohol, caution is essential when taken together, and all current medications should be disclosed to healthcare professionals. Women who are pregnant or breastfeeding should not take this drug, and safety in children and adolescents has not been established, so use is not recommended. In elderly patients, drug concentrations may increase due to reduced liver function, and excessive blood pressure reductions can pose risks such as strokes, so it is advisable to start with low doses and use caution. In cases of overdose, symptoms may include a drop in blood pressure, decreased heart rate, weakened heart function, shock, respiratory distress, and altered consciousness, requiring immediate medical attention. This drug is not removed by hemodialysis, thus antidotes and supportive treatment may be necessary.

Dizziness, headache, fatigue, weakness, hallucinations, confusion, depression, sleep disturbances, nightmares, psychosis, severe bradycardia, shock, complete heart block, heart failure, cardiac arrest, hypotension, loss of consciousness, decreased pulse rate, cold extremities, edema, asystole, renal function deterioration, renal failure, increased resistance in the respiratory tract, nausea, diarrhea, abdominal pain, vomiting, constipation, hives, itching, lichenoid reactions, sweating, allergic rash, changes in serum aminotransferases, thrombocytopenia, leukopenia, hypoglycemia, masking of hyperthyroid function, hyperglycemia, weight gain, increased cholesterol levels, bradycardia, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, decreased tear production, sensory disturbances, visual disturbances, eye irritation, dry mouth, urinary disorders, sexual dysfunction, allergic reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, blood pressure reduction, decreased heart rate, cardiac weakening, cardiogenic shock, asystole, cardiac arrest, dyspnea, bronchospasm, vomiting, altered consciousness, generalized seizures

This drug is sensitive to light and should be stored in a container that prevents light exposure. Additionally, it is important to store the medication at room temperature, which is between 1 degree and 30 degrees Celsius. Doing so will help maintain its effectiveness and safety over time.

Appearance

Brownish-red round tablets

Package unit

100 tablets (10 tablets/PTP X 10)