Rogmycin Tablet (Roxithromycin)

Adult dose

Adults: Administer 150 mg (potency) of roxithromycin orally per dose twice daily, before breakfast and dinner. For pneumonia, administer 300 mg (potency) once daily before breakfast. Adjust the dose appropriately according to age and symptoms.

Child dose

Children: The average dose used in clinical trials was 6 mg (potency) per kg of body weight per day. Administer 5–8 mg (potency) per kg of body weight per day orally in 2 divided doses. Children weighing 6–11 kg: Take 25 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 2.5 mL per dose twice daily before meals (suspension only). Children weighing 12–23 kg: Take 50 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 5 mL per dose twice daily before meals (suspension only). Children weighing 24–40 kg: Take 100 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 10 mL per dose twice daily before meals (suspension only).

This medication can rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis; therefore, if symptoms such as skin blistering or mucosal lesions occur, use should be discontinued immediately. This drug should not be used in patients with hypersensitivity to macrolide antibiotics or those taking specific medications (terfenadine, astemizole, cisapride, pimozide, ergot alkaloids, mizolastine). It should be used cautiously in patients with liver dysfunction or the elderly, and when used with other antibiotics, care must be taken regarding resistance or side effects. This drug can also affect heart rhythm; therefore, caution is advised for patients with congenital heart rhythm abnormalities or those taking specific antiarrhythmic medications. This drug may exacerbate symptoms of myasthenia gravis, so caution is required for patients with this condition. Adverse reactions such as allergic reactions, blood disorders, liver function abnormalities, gastrointestinal issues, severe diarrhea, respiratory difficulties, neurological abnormalities, changes in taste and smell, skin rashes, etc., may occur during treatment, and if any abnormal symptoms arise, patients should consult healthcare professionals immediately. Particularly during prolonged use, there can be a risk of resistant bacteria and superinfection; hence, the condition should be monitored closely. Periodic testing is necessary if liver function is impaired, and dosage adjustment is not required in patients with poor kidney function. The recommended dosage and duration of treatment must be adhered to in children, as overdose may affect bone growth. This drug may interfere with the metabolism of other medications in the liver, potentially increasing their blood concentrations, so caution is needed when co-administering with certain drugs. Women who are pregnant or may become pregnant should carefully decide on the use of this drug as it may affect the fetus; if breastfeeding, it is recommended to avoid use or discontinue breastfeeding if possible. While no dose adjustment is needed for the elderly, close observation of physical responses is essential. This drug may cause dizziness and visual disturbances, so caution is needed when operating machinery or driving. Lastly, this medication should be stored out of reach of children, and transferring it to another container may affect its quality.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, increased serum bilirubin, anorexia, nausea, vomiting, epigastric discomfort, gastric pain, abdominal pain, abdominal distention, diarrhea, membranous colitis, watery stools, hematochezia, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue paresthesia, paralysis, dysgeusia, ageusia, olfactory disturbances, anosmia, erythema multiforme, purpura, secondary infections due to overgrowth of non-susceptible pathogens, transient hearing loss, hearing impairment, visual disturbances, blurred vision, conjunctival injection, generalized fatigue, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual abnormalities, inflammation of the oral and vaginal mucosa, hallucinations, confusion

This drug should be stored in a sealed container to prevent exposure to air or moisture. When storing, avoid places that are too hot or too cold, and it is best to keep it at room temperature.

Appearance

White, round, biconvex film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle