Dae Hwa Ceftriaxone Injection 1 Gram (Ceftriaxone Sodium Hydrate)

Adult administration

For adults and children over 12 years old, administer 1-2 g (potency) of ceftriaxone once daily by intravenous or intramuscular injection. For infections caused by severe or moderately susceptible pathogens, the dose may be increased up to 4 g (potency) once daily. For gonorrhea treatment, a single intramuscular injection of 250 mg (potency) is recommended. To prevent infections before and after surgery, it is advisable to administer 1-2 g (potency) once 30-90 minutes prior to surgery based on the risk factors for infection.

Child administration

For newborns (within 14 days of birth), administer 20-50 mg (potency) per kg of body weight once a day, not exceeding 50 mg (potency) per kg of body weight. For infants and children (15 days to 12 years), the dosage is based on their body weight.

This medicine must not be mixed or administered simultaneously with solutions containing calcium. Especially in newborns, mixing calcium with this medicine can cause precipitation and serious side effects, so it must never be administered. Patients with allergies to this medicine or who have had hypersensitivity reactions to cephalosporins or penicillin antibiotics should not use it. If there is an allergy to the local anesthetic lidocaine, it should not be administered intramuscularly. Newborns with conditions such as prematurity, jaundice, hypoalbuminemia, or acidosis should not be given this medicine, as it may lead to the removal of bilirubin from blood and cause brain damage. This medicine may cause changes in blood cell counts, diarrhea, rash, liver dysfunction, etc. If any abnormal symptoms occur, medical professionals should be informed immediately. During administration, it is important to regularly check liver and kidney functions, and blood tests for abnormalities. Caution is also needed when driving or operating machinery while receiving this medication. This medicine can interact with other medications; extra caution is advised when used with diuretics, aminoglycoside antibiotics, and calcium-containing solutions as there is a risk of worsening renal function or precipitate formation. Pregnant or nursing women should consult a doctor before administering this medicine, as it may affect the fetus or baby. This medicine may not be safe for newborns and preterm infants, particularly those with high bilirubin levels. Elderly patients may show more pronounced side effects due to decreased body functions; therefore, monitoring and dosage adjustment may be necessary. This medicine may affect blood sugar tests or urine tests, so medical staff should be informed that this medicine is being taken during testing. Intravenous injection may cause pain or inflammation at the injection site, and administration should be done slowly. It should be used as soon as the solution is prepared and stored at the appropriate temperature.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, high fever with severe rash, blisters, skin peeling, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination issues

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medicine should be stored in a sealed container to prevent air exposure and should be kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the efficacy of the medication for a longer time.

Appearance

A vial containing a white to pale yellow powder

Package unit

For domestic use - 1 vial/box [1 gram/vial × 1], For domestic use - 10 vials/box [1 gram/vial × 10]