Metronidazole Injection (Metronidazole Preparation)

Adult dosage

Trichomoniasis: Administer 250 mg of metronidazole orally twice a day for 10 days. Treatment of anaerobic infections: Administer 500 mg orally 3 to 4 times a day. The maximum daily dose should not exceed 4 g, and treatment generally lasts for 7 to 10 days. Prevention of anaerobic infections after surgery: Administer 1 g initially, followed by 250 mg orally 3 times a day.

Children's dosage

When using injection 1. Treatment of anaerobic bacterial infections - Children aged 12 and older: Administer 500 mg (100 mL) every 8 hours intravenously followed by oral administration. - Children under 12 years: 1 daily

This drug has been reported to cause tumor occurrence in rodent animal experiments and should not be used unnecessarily. In patients with cocaine syndrome, this drug can cause severe hepatotoxicity or acute liver failure, so liver function tests should be performed and caution is warranted. Patients with hypersensitivity to this drug, blood diseases, organic nervous system diseases, in early pregnancy, or those taking certain medications should not be treated with this drug. Severe adverse reactions can occur when taken with alcohol, so alcohol intake should be avoided for at least 3 days during and after administration. Patients with liver dysfunction, those in late pregnancy, central nervous system diseases, and those with impaired heart or kidney function should use this drug cautiously. This drug can cause various side effects in the digestive system, blood system, skin, nervous system, etc., so any unusual symptoms should be reported to healthcare professionals immediately. Patients with severe liver disease may require dose adjustments as this drug and its metabolites can accumulate in the body, and regular monitoring during treatment is recommended. When taking this drug, confusion, drowsiness, hallucinations, seizures, visual disturbances, etc., can occur, so driving or operating machinery should be avoided. This drug can affect blood coagulation, so patients on anticoagulants need to monitor blood levels for dose adjustments. There are interactions with lithium, alcohol, disulfiram, some anticonvulsants, immunosuppressants, etc., so it is essential to inform about any medications being taken. During pregnancy, it may affect the fetus, so especially early pregnant women should avoid use, and breastfeeding should be suspended during treatment. In case of overdose, there is no specific antidote, and general treatment should be received. This drug should not be mixed when used with other antibiotics and must be used specifically for intravenous administration during infusion.

Serious side effects

• Urticaria, angioedema, anaphylactic shock → severe allergic reactions
• Hepatitis and jaundice, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP) → severe skin adverse reactions
• Convulsive seizures, encephalopathy (confusion), subacute cerebellar syndrome (ataxia, speech impairment, gait disturbance, eye tremors

Mild side effects

• Nausea
• vomiting
• diarrhea
• oral mucositis
• taste disturbance
• loss of appetite
• abdominal pain
• increased serum amylase
• rarely reversible pancreatitis
• moderate reversible leukopenia

This drug should be stored in a tightly sealed container that can block light, and the temperature should be kept between 1 to 30 degrees Celsius at room temperature. This way of storage helps maintain the drug's efficacy and safety.

Appearance

A colorless to pale yellow transparent liquid filled in a colorless transparent glass or plastic container.

Package unit

100 milliliters per bottle, 100 milliliters per pack