Sguimin Injection (Pyridostigmine Bromide)

Adult dosage

1. Reversal or antagonism of nondepolarizing muscle relaxants before or after surgery: Usually, inject 10-20㎎ (0.1-0.25㎎ per kg of body weight) of pyridostigmine bromide. When this medicine is administered intravenously, it is preferable to administer atropine sulfate 0.6-1.2㎎ or glycopyrrolate (in an amount that can produce an effect similar to atropine) immediately before or at the same time as this medicine to reduce adverse effects such as bradycardia or excessive secretions. 2. 1) For use before or after surgery and during or after delivery in myasthenic crisis: Administer intramuscularly or by slow intravenous injection an amount equivalent to 1/30 of the oral dose (2-6㎎). 2) For use during labor to maintain adequate muscle tone in the pregnant patient or to protect the newborn immediately after delivery: Inject 1 hour before the second stage of labor.

Children's dosage

When a newborn born to a mother with symptoms of myasthenia gravis has respiratory distress, difficulty swallowing, or temporary difficulty feeding: Inject an amount equivalent to 0.05-0.15㎎ per kg of body weight intramuscularly.

This medication is provided in the form of an ampoule injection and care must be taken when opening the container, as glass shards may be present. Special caution should be exercised when used in children or the elderly. This medication should not be used in certain patients, such as those allergic to this drug or similar medications, those with gastrointestinal or urinary obstruction or stenosis, patients with bronchial asthma, iritis, hyperthyroidism, myotonia, Parkinson's syndrome, those in shock post-surgery or with cardiovascular disease, and patients receiving certain muscle relaxants. Patients with renal impairment, peptic ulcers, those who have undergone gastrointestinal surgery, diabetes, liver damage, heart failure, recent myocardial infarction, arrhythmia, bradycardia, or hypotension should use this medication cautiously and should have regular liver function tests. Overdosage can lead to symptoms such as respiratory muscle paralysis, abdominal pain, diarrhea, sweating, and pinpoint pupils, and in such cases, immediate discontinuation and appropriate treatment should be sought. Various side effects may occur, including diarrhea, nausea, vomiting, abdominal pain, tearing, sweating, increased bronchial secretion, abdominal cramps, vasomotor congestion, increased peristalsis, muscle cramping, fasciculations, weakness, skin rashes, thrombophlebitis, and bradycardia. In myasthenia gravis patients, symptoms may worsen, so careful monitoring is needed.

• Respiratory muscle paralysis
• idiopathic myoclonus
• abdominal pain
• diarrhea
• sweating
• flexibility
• miosis
• nausea
• vomiting
• abdominal distension

This medication should be stored in a container that blocks light, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage will ensure that the medication's components remain unchanged and its effectiveness is well maintained.

Appearance

A colorless and transparent liquid contained in a brown ampoule.

Package unit

For domestic use - 50 ampoules/box [(1 milliliter/ampoule)], for export - 10 ampoules/box [(1 milliliter/ampoule)]