Hulgram 600mg Injection (Clindamycin Phosphate)

Adult administration

For severe infections, administer 600–1200 mg (based on weight) of clindamycin phosphate per day divided into 2–4 intravenous or intramuscular injections. For severe infections, administer 1200–2700 mg (based on weight) per day divided into 2–4 injections. In emergencies, the dose may be increased up to 4.8 g (based on weight) for intravenous injection. The injection should be administered slowly over 10–60 minutes, taking into account blood concentration maintenance lines.

Child administration

For children (over 1 month), in cases of severe infection, administer 15–25 mg (based on weight) per day divided into 3–4 intravenous or intramuscular injections. For severe infections, administer 25–40 mg based on weight per day divided into 3–4 doses.

This drug is used for the treatment of severe infections and may sometimes cause severe colitis, so caution is needed. Particularly, if severe and persistent diarrhea, abdominal pain, or fever occurs, consult a doctor immediately. This drug does not penetrate well into cerebrospinal fluid and is not suitable for treating meningitis. Caution must be observed when using the injection to avoid the presence of glass particles; especially, greater care should be taken with children and the elderly. Due to the presence of benzyl alcohol, it should not be administered to neonates or premature infants. Those with a history of allergy to lincomycin or clindamycin should not use this drug. Elderly or frail patients, and those with impaired liver or kidney function should use this drug cautiously. This drug may cause pain or numbness at the injection site when given intramuscularly, and thrombophlebitis may occur when administered intravenously. Gastrointestinal disturbances such as diarrhea, nausea, and vomiting may occur, and if severe allergic reactions or skin rashes develop, treatment should be discontinued immediately. Regular checks are necessary for long-term use as it may impact liver and kidney function. This drug may interact with other medications, especially muscle relaxants, anticoagulants, and certain antibiotics. Pregnant or breastfeeding women should avoid using this drug, and special caution is required when administering it to neonates or children as safety has not been established. In the case of overdose, since there are no specific antidotes, appropriate emergency treatment should be given based on the symptoms, and careful attention should be paid to storage conditions to ensure it is used within its expiration period. This drug's effects on driving or operating machinery are not clearly established, so caution is advised.

Serious side effects

Severe colitis, diarrhea, bloody stools, pseudomembranous colitis, peritonitis, shock, toxic megacolon, hives, severe edema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory irregularities accompanied by cough and fever, jaundice of skin or eyes

Mild side effects

• Pain at the injection site
• numbness
• non-bacterial abscesses
• thrombophlebitis
• diarrhea
• loose stools
• loss of appetite
• nausea
• vomiting
• abdominal pain

This drug should be stored in a sealed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and safety over time.

Appearance

Colorless and transparent injection contained in a brown ampoule

Package unit

4mL - 10 ampoules per box