Bonkey 1 Microgram (Calcitriol)

Adult administration

The initial recommended regimen and dosage for this drug is to administer 0.5 ㎍ of calcitriol three times a week (approximately 0.01 ㎍ per kg body weight) on alternate days. This drug can be administered as an IV bolus through a catheter at the end of hemodialysis. If there is no satisfactory response after biochemical tests and clinical symptoms, the dosage may be increased by 0.25 to 0.50 ㎍ at intervals of 2 to 4 weeks. Most hemodialysis patients show effects with a dosage of 0.5 to 3 ㎍ three times a week.

Care should be taken to cut the glass ampoule carefully to avoid glass fragments when using an ampoule made of glass. Extra caution is required when used by children or the elderly. This medication should not be used in patients who are allergic to this drug or its ingredients or those who have hypercalcemia. Additionally, patients showing symptoms of vitamin D overdose should not be administered this medication. Women who are pregnant or breastfeeding should use this drug cautiously, considering the potential effects on the fetus or infant. Rarely, serious allergic reactions or redness and pain at the injection site may occur. In cases of overdose, various symptoms such as digestive disorders, neurological issues, cardiac problems, or skeletal pain may occur, so caution is required. To enhance treatment efficacy, patients should consume adequate calcium daily and regularly check calcium intake and blood calcium levels. In cases of overdose, dosing should be stopped immediately, and periodic checks of blood calcium levels should be conducted. This drug may interact with certain medications, so if other medications are being taken, consultation with a doctor or pharmacist is necessary. Caution is especially needed when using medications containing magnesium antacids, cardiac drugs, and anticonvulsants. During pregnancy or lactation, the use of this drug may pose risks to the fetus or infant, and should only be used when absolutely necessary. It is advisable to avoid administration during breastfeeding if possible. Safety in pediatric patients has not been established, so it should be used cautiously in children. Elderly patients may have reduced body functions, so dosing should be adjusted appropriately. In cases of overdose, administration should be stopped immediately, a low-calcium diet should be implemented, and blood calcium levels should be checked frequently. Dialysis or pharmacological treatment may be necessary according to need. Before administration, check for any abnormalities in the injection solution, do not mix with other medications, and use promptly after opening, disposing of any remaining medication.

Serious side effects

Anaphylaxis, high fever, chest tightness, liver abnormalities (including elevation of ALT and AST), confusion, severe edema, hypercalcemia, arrhythmias, palpitations, atrioventricular block, atrial fibrillation, osteomalacia, nephrocalcinosis, systemic vascular calcification, severe neurological symptoms, elevated blood pressure and severe edema

Mild side effects

• Localized redness at the injection site
• mild pain
• thirst
• polydipsia
• nausea
• vomiting
• dry mouth
• constipation
• metallic taste
• loss of appetite

This drug may be sensitive to light, so it should be stored in a light-tight sealed container. It is also advisable to store the drug at room temperature, meaning at a generally comfortable indoor temperature that is neither too hot nor too cold.

Appearance

A brown ampoule injection containing a colorless to pale yellow transparent liquid

Package unit

10 ampoules (1 mL/ampoule x 10)