Aroxol Injection (Ambroxol Hydrochloride)

Adult administration

As Ambroxol Hydrochloride, slowly inject 15 mg per dose, 2 to 3 times a day. In severe cases, the dosage can be increased to 30 mg per dose, and it can be administrated as an intravenous drip with saline injection or Ringer's solution. For those over 5 years old, administer 15 mg per dose, 2 to 3 times a day.

Child administration

For children, slowly administer 1.2 to 1.6 mg per kg of body weight as an intravenous injection. For ages 2 to 4 years, administer 7.5 mg per dose, 3 times a day. For under 2 years old, administer 7.5 mg per dose, 2 times a day. Respiratory distress syndrome.

Since this medication is in a glass ampoule injection, great care must be taken when cutting the container as glass fragments may mix in. Precaution is especially necessary when used in children and the elderly. This medication should not be used by individuals allergic to it or its components. Patients with poor kidney function, severe liver dysfunction, and infants under 2 years old should use this medication with caution. Rarely, serious adverse reactions such as severe skin damage may occur; if new damage to the skin or mucous membranes occurs, use should be stopped immediately, and treatment should be obtained. Gastrointestinal discomfort may occur, including indigestion, nausea, vomiting, heartburn, and dryness of the mouth, which can be seen occasionally. Rarely, there may be discomfort or bloating in the stomach or abdomen, abdominal pain, diarrhea, constipation, and loss of appetite. Skin rashes or severe allergic reactions, hives, facial swelling, and difficulty breathing have been reported rarely; if these symptoms occur, immediate consultation with a physician is required. Inflammation in the respiratory system may occur, and sensory abnormalities of the tongue, taste changes, and rarely, oral paralysis or arm paralysis may be observed in the nervous system. This medication may increase the concentration of antibiotics in bronchial and pulmonary secretions when used with certain antibiotics; thus, consultation with a physician is necessary when used in combination. This medication is not recommended during pregnancy, especially in the first three months, and should be administered cautiously in the later stages of pregnancy. For breastfeeding women, this medication may be transmitted through breast milk, so it should only be used if the benefits of treatment outweigh the risks. Elderly patients may have decreased physical function, and caution should be taken in reducing the dosage when using this medication. No specific symptoms have been reported in the case of overdose; however, treatment may be necessary for emerging adverse reactions. During injection, headaches, leg pain, and extreme fatigue may occur, so it is advisable to inject slowly. This medication should only be mixed with saline solution or Ringer's solution for intravenous drip administration, and the mixed solution should be used within 24 hours at room temperature. This medication should be stored in a secure place away from children's reach.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, severe acute anaphylactic reactions (including anaphylactic shock), angioedema, facial swelling, Stevens-Johnson syndrome, serious skin damage such as toxic epidermal necrolysis (Lyell's syndrome).

Mild side effects

• Indigestion
• nausea
• vomiting
• heartburn
• dry mouth
• discomfort in the stomach
• abdominal bloating
• abdominal pain
• diarrhea
• constipation

This medication is sensitive to light, so it should be stored in a container that blocks light. Additionally, it is best to store the medication at room temperature between 1 degree and 30 degrees.

Appearance

A colorless, transparent solution in a brown ampoule for injection.

Package unit

50 ampoules/box [(2 milliliters/1 ampoule)]