Cheil Cilazapril Tablet 1.0 mg (Cilazapril Hydrate)

Adult dose

This medicine should be administered once daily at the same time each day. Since food intake does not significantly affect absorption, it may be administered before or during a meal. Measure blood pressure after 4 weeks of treatment and adjust the dose if necessary. Adults with essential hypertension: The usual dose is 2.5 ∼ 5 mg of anhydrous cilazapril orally once daily. For the first 2 days, a dose of 1 ∼ 1.25 mg once daily is recommended. The dose should be adjusted individually according to the blood pressure response. If blood pressure is not controlled with 5 mg daily, this medicine may be given in combination with a low dose of a non-potassium-sparing diuretic. An adequate therapeutic effect generally does not occur until 2 ∼ 4 weeks after starting treatment. Adults with renovascular hypertension: Since the blood pressure-lowering effect of ACE inhibitors may be more pronounced in patients with renovascular hypertension than in those with essential hypertension, treatment should be started at a dose of 0.5 mg once daily or a lower dose, and the maintenance dose should be determined individually. Hypertensive patients taking diuretics: Patients taking diuretics are often volume depleted or more susceptible to hypotension caused by ACE inhibition; therefore, treatment should be initiated with caution. If possible, discontinue all diuretics 2 ∼ 3 days before administering this medicine. If they cannot be discontinued because of the patient's condition, start treatment with a dose of 0.5 mg once daily and monitor blood pressure closely after the first dose until it stabilizes. The maintenance dose should be adjusted according to each patient's response. Patients with renal impairment: Creatinine clearance (mL/min) ＞ 40: initial dose 1mg once daily, maximum dose 2.5~5mg once daily Creatinine clearance (mL/min) 10 ∼ 40: initial dose 0.5mg once daily, maximum dose 2.5mg once daily Creatinine clearance (mL/min) ＜ 10: Not recommended Patients requiring hemodialysis should take this medicine on days when dialysis is not performed, and the dose should be adjusted according to the blood pressure response. Older adults: Initiate treatment with 0.5mg ~ 1mg once daily or a lower dose, depending on the patient's fluid status and general condition. The maintenance dose should be adjusted according to the individual response. Patients with cirrhosis: In patients with cirrhosis who do not have ascites, the dose of this medicine should not exceed 0.5 mg daily. Since severe hypotension may occur when treating hypertension in these patients, prescribe with great caution and carefully monitor blood pressure.

This medication can cause serious harm to the fetus during pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Individuals who have had an allergic reaction to this medication or its ingredients should not take it. Patients with a history of angioedema, those undergoing blood component collection, patients undergoing certain types of dialysis, patients with liver cirrhosis, children, adolescents, and those with specific kidney diseases may be at risk when taking this medication, so caution is necessary. Patients with severe kidney disease, renal artery stenosis, or hyperkalemia should use this medication with caution as it may cause deterioration of kidney function or hypotension. Patients with severe hypertension, those with depleted fluids, heart failure patients, the elderly, patients with liver cirrhosis, and nursing mothers are at risk of hypotension and should start with a low dose and gradually increase while monitoring closely. This medication can cause various side effects including dry cough, rash, hypotension, dizziness, fatigue, headache, dyspepsia, among others, and serious allergic reactions, deterioration of kidney function, blood abnormalities, liver function abnormalities, and skin reactions can occur; therefore, one should consult a doctor immediately if any unusual symptoms arise. In particular, if there is a rapid drop in blood pressure or symptoms of angioedema appear, the medication should be discontinued immediately and emergency care should be sought. This medication may have increased side effects or effects when combined with other antihypertensives, potassium-sparing diuretics, certain antibiotics, or immunosuppressants. If you are taking any other medications, it is essential to inform your doctor or pharmacist. Women who are pregnant or planning to become pregnant, as well as nursing women, should avoid using this medication, and if unavoidable, they should discontinue breastfeeding. Safety in children and adolescents has not been established, so it is recommended not to use it. Elderly individuals should periodically test kidney function and serum potassium levels, and treatment should start at a low dose and be given cautiously. During the course of treatment, regular checks on blood pressure, kidney function, and electrolyte status should be conducted, taking appropriate action if abnormalities are found. In case of overdose, symptoms such as hypotension, shock, or acute kidney failure may occur, so immediate medical attention is needed, and if necessary, the drug may be removed via dialysis. This medication should be stored out of reach of children and should not be transferred to another container, as this is important for maintaining quality.

• Dry cough
• rash
• hypotension
• dizziness
• fatigue
• headache
• nausea
• indigestion
• itching
• angioedema

This medication should be stored in a sealed container to prevent air exposure and kept in a cool place between 1 and 25 degrees Celsius. Proper storage will help maintain the effectiveness of the medication and prevent degradation.

Appearance

Pale yellow round film-coated tablet

Package unit

30 tablets (10 tablets/PTPX3)