Dodeamin Injection

Adult dosage

As total amino acids, 1 to 1.5 g per kg of body weight should be administered intravenously as a maximum dose per day. The recommended infusion rate is a concentration of about 10 g of total amino acids over 60 minutes, adhering to the principle of bolus infusion at a maximum rate of 25 drops per minute.

Children's dosage

For children, the dosage and infusion rate should be adjusted appropriately.

This medication must be used according to the physician's instructions, and it should not be taken or stopped arbitrarily. It should not be administered to patients with hepatic coma or those at risk of hepatic coma, severe kidney disorders, or nitrogen metabolism disorders. Use should also be avoided in patients with severe heart failure, pulmonary edema, extremely low or no urine output, and specific electrolyte abnormalities. Additionally, it should not be given to patients with heart conduction disorders, myasthenia gravis, patients receiving excessive fluid supply, patients with acidosis, patients with hyperkalemia, neonates, children under 2 years old, and patients who have had a myocardial infarction. Caution is needed for patients with congestive heart failure or edema due to sodium retention, as well as those with liver or kidney disorders, as adverse reactions may include skin rashes, nausea, vomiting, palpitations, and blood pressure elevation. Rapid or large volume administration may result in acidosis, and symptoms such as fever, chills, headache, and shortness of breath may rarely occur, which requires caution. During the use of this medication, it is crucial to maintain a good electrolyte balance, and patients with diabetes should frequently check their blood sugar levels. There may be drug interactions with other medications; thus, caution is required if used with tetracycline antibiotics or calcium salts. Safety during pregnancy has not been established, so it should only be administered under the physician's judgment when necessary. This medication should not be given to infants under 2 years of age, and when used in children, blood ammonia levels should be frequently monitored. Elderly patients may have diminished bodily functions, so the administration rate should be slow and the dosage should be adjusted. During administration, the infusion should be given slowly IV, the temperature of the solution should be maintained at body temperature, and it is essential to prepare and manage the solution in a sterile condition. The solution should not be used if it appears discolored or cloudy prior to administration, and it should be stored in unopened packaging and used as soon as possible after opening.

Serious side effects

• Respiratory issues: Difficulty breathing, respiratory arrest, shock, bronchospasm
• Liver issues (jaundice): Liver failure, elevated liver enzymes, liver enzyme imbalance, hyperammonemia, loss of sensation, coma
• Severe allergic reactions: Rarely occurring hypersensitivity
• Severe edema or urinary issues: Oliguria, anuria
• Serious neurological symptoms: Headache, loss of sensation, coma
• Edema accompanied by elevated blood pressure: Includes symptoms associated with elevated blood pressure

Mild side effects

• Allergic reactions: Symptoms such as rash
• Gastrointestinal: Nausea, vomiting
• Cardiovascular: Chest discomfort, palpitations, tachycardia, elevated blood pressure
• Others: Warm sensation, vascular pain, chills, fever, headache, urinary spasms, peripheral vascular dilation
• Metabolic complications: Metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, osmotic diuresis and dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin deficiencies and excesses, electrolyte imbalances, pediatric hyperammonemia

This medication should be stored in a sealed container to prevent exposure to air and moisture, preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way helps to maintain the effectiveness of the medication.

Appearance

A colorless to pale yellow transparent solution filled in a colorless transparent glass container or polypropylene container as an injectable solution.

Package unit

250mL/bottle