Quran Injection 100 mg (Ranitidine Hydrochloride)

Adult dosage

As ranitidine, administer 50 mg by intravenous or intramuscular injection 3-4 times a day. For intravenous injection, dilute 50 mg in 20 ml of normal saline or dextrose solution and administer slowly over at least 2 minutes, or mix it with fluid and administer as a slow intravenous infusion at a rate of 25 mg/hr for 2 hours. For pre-anesthetic administration (to prevent Mendelson's syndrome), 50 mg should be injected intramuscularly or slowly intravenously over 1 minute 45-60 minutes before anesthesia induction.

Children's dosage

Clinical studies for children have not been established.

This medication is an ampoule injection, and care should be taken when opening the container as glass fragments may be included. Extra caution is necessary when using it on children or elderly patients. Patients with allergies to this medication or its components should not receive it. For patients with poor kidney function, this medication may remain in the body for a long time, thus requiring a dose reduction or increased dosing interval, and it should also be used cautiously in patients with impaired liver function. Patients with a history of drug allergies, the elderly, and those with a history of acute porphyria should also be given this medication with caution. This drug can rarely cause severe allergic reactions or anaphylactic shock, so the patient's condition should be closely monitored during administration, and if any unusual symptoms occur, administration should be stopped immediately and appropriate treatment should be sought. Blood-related side effects may include a decrease in white blood cells or platelets, so if symptoms such as fatigue, bleeding, or fever occur, a blood test should be conducted, and if necessary, drug administration should be stopped. Liver function impairments may occur temporarily, so if symptoms of jaundice or hepatitis appear, use should be stopped immediately. Cardiovascular anomalies, such as arrhythmias or hypotension, and breathing difficulties can occur but are rare. Gastrointestinal side effects may include constipation, nausea, and abdominal pain. Neurological side effects such as dizziness, drowsiness, headache, confusion, depression, and hallucinations may occur, especially in patients with impaired kidney function, requiring more caution. Endocrine side effects, such as gynecomastia and decreased sexual function, have also been reported rarely. Musculoskeletal side effects may include muscle pain or rhabdomyolysis; any unusual symptoms should be reported to medical personnel immediately. Skin rash, hair loss, and itching may occur. This medication should only be used for the minimum duration necessary to confirm treatment efficacy, and if ineffective, other treatment options should be considered. Elderly patients or those with chronic illnesses may have an increased risk of pneumonia, requiring caution. If given intravenously at high doses for more than 5 days, liver enzyme levels may rise, necessitating regular liver function tests. When oral administration is possible, it is recommended to switch to oral medication as soon as practicable. This medication may affect the absorption or metabolism of other drugs, so dosage adjustments may be necessary when combined with other medications; consultation with a specialist is advised. Women who are pregnant or may become pregnant, and breastfeeding women should only receive this medication with caution when necessary. Safety in children has not been adequately established, so caution is required when using it. This medication may also affect some clinical test results, necessitating adjustments to testing methods. In the case of overdose, symptomatic treatment such as vomiting and gastric lavage is required, and in severe cases, blood dialysis can be performed. Pain or induration may occur at the injection site, and in patients with arrhythmias, slow injection should be performed. This medication may mask symptoms of gastric cancer, so patients with gastric ulcers or newly developed dyspepsia, especially those over middle age, should confirm whether the condition is malignant before use. Long-term use may affect eye health, so regular ophthalmologic examinations are necessary.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, chest pain, difficulty breathing (bronchospasm), cold sweat, pallor, anaphylactic shock, severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa, severe skin reactions, hematological abnormalities (neutropenia, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, agranulocytosis, pancytopenia, and more.

Mild side effects

Headache, dizziness, drowsiness, insomnia, agitation, anxiety, generally reversible mental confusion primarily in severe and elderly patients, depression, hallucinations, transient blurred vision, involuntary movement disorders, gynecomastia, galactorrhea, erectile dysfunction, decreased libido, joint pain, muscle pain, skin rash, mild erythema multiforme, alopecia, glossitis, pruritus, constipation, nausea, vomiting, abdominal distension, abdominal pain, anorexia, diarrhea.

This medication should be stored in a cool place below 30 degrees Celsius, and should be kept in a sealed container to prevent exposure to light. This will help maintain the medication's efficacy and prevent degradation.

Appearance

A clear colorless to pale yellow liquid in a brown ampoule.

Package unit

50 ampoules/box [(4ml/ampoule)]