Nadoksal Injection (Ambroxol Hydrochloride)

Adult administration

As Ambroxol Hydrochloride, administer 15 mg once, 2–3 times a day slowly intravenously. In severe cases, it may be increased to 30 mg at once and can be administered by dripping intravenously with normal saline or Ringer's solution.

Child administration

Administer slowly intravenously at 1.2–1.6 mg per kg of body weight per day. Dosing by age is as follows: - Age 5 and older: 15 mg once, 2–3 times a day - Age 2–4: 7.5 mg once,

This drug is a glass ampoule injection, and caution should be exercised when cutting the container, as glass fragments may mix with the solution. Extra care must be taken, especially when used on children or the elderly. This drug should not be used in patients with allergic reactions to this drug or its components. Special caution is needed when using this medication in patients with poor kidney function, severe liver dysfunction, and infants under 2 years old. Rarely, serious skin conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur, so if new skin or mucosal damage appears, use should be immediately discontinued and medical attention sought. Gastrointestinal symptoms may include heartburn, nausea, vomiting, indigestion, and, less commonly, abdominal pain or diarrhea. Allergic reactions such as skin rashes, urticaria, and respiratory distress may occur rarely, and if any unusual symptoms appear, immediate consultation with a physician is essential. Respiratory symptoms may include purulent rhinitis, while neurological symptoms may include altered taste sensation or, rarely, arm numbness. Caution is advised when this drug is used in conjunction with certain antibiotics, as it may increase the concentration of the antibiotics. Usage during pregnancy, especially during the first trimester, is not recommended, and nursing women should use this drug cautiously after consulting with a physician, as it may be transmitted through breast milk. Elderly patients may have reduced body function, so dosage adjustments may be necessary. No specific symptoms have been reported in cases of overdose, but if any adverse reactions appear, medical personnel should be notified immediately for appropriate treatment. When injecting, headaches, leg pain, and extreme fatigue may occur, so it should be administered slowly. This medication should only be mixed with normal saline or Ringer's solution. The mixed injection solution should be administered within 24 hours at room temperature and stored in a safe place out of the reach of children.

Serious side effects

Urticaria, angioedema, respiratory distress, severe acute anaphylactic reactions (including anaphylactic shock), Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome).

Mild side effects

Indigestion, nausea, vomiting, heartburn, dry mouth, discomfort in the stomach, bloating, abdominal pain, diarrhea, constipation, loss of appetite, skin rashes, urticarial erythema, itching, facial swelling, chills, purulent rhinitis associated with increased white blood cells, altered taste sensation, oral numbness, arm numbness, headaches, leg pain, extreme fatigue.

This drug is sensitive to light and should be stored in a container that does not allow light exposure. Additionally, it should be kept at room temperature, ideally between 1 to 30 degrees Celsius.

Appearance

A colorless, transparent liquid contained in a brown ampoule for injection.

Package unit

For domestic use - 100 ampoules/box [(2mL X 100)], for export - 10 ampoules/box [2mL X 10], for export - 50 ampoules/box [2mL X 50]