Ativan Injection (Lorazepam)

Adult dosage

(Oral: tablets) ○ Adults: Administer 1-4㎎ of lorazepam orally in 2-3 divided doses per day. In severe cases, up to 20㎎ per day may be administered. Adjust the dose as appropriate according to age and symptoms. (Injection) ○ Adults 1. Preanesthetic medication Usually, inject 0.05㎎ per ㎏ of body weight. With intravenous administration, sedation occurs 5-10 minutes after administration and memory is maximally reduced after 30-45 minutes; therefore, administer 30-45 minutes before surgery. With intramuscular administration, sedation occurs 30-45 minutes after administration and memory is maximally reduced after 60-90 minutes; therefore, administer 60-90 minutes before surgery. 2. Acute anxiety Inject 0.025-0.03㎎ per ㎏ of body weight every 6 hours. This injection may become slightly viscous in a cool environment. To facilitate injection, immediately before administration, prepare a 1 : 1 dilution with normal saline injection or distilled water for injection. It may then be administered intravenously or intramuscularly, although intravenous administration is preferred. Adjust the dose as appropriate according to age and symptoms.

This medication may cause fatal respiratory issues in premature infants if it contains benzyl alcohol, thus caution is advised. Caution is required when using narcotics and benzodiazepines, including this medication, together as there is a risk of sedation, respiratory depression, coma, and death; use the minimum dose for the shortest duration necessary. This medication has a risk of abuse and addiction, so patients should be closely monitored, and it should not be used with alcohol or other central nervous system depressants. It should not be administered to specific patients such as those with myasthenia gravis, acute narrow-angle glaucoma, severe respiratory failure, sleep apnea syndrome, patients with alcohol or drug dependence, neonates, and premature infants. Patients with heart, kidney, or liver dysfunctions, elderly patients, and those with depression should use this medication cautiously, remaining vigilant for symptom exacerbation or side effects. This medication can induce psychological dependence and withdrawal symptoms; dosage should be adjusted and abrupt discontinuation should be avoided, and paradoxical reactions may occur in mentally ill patients which requires monitoring. Drowsiness and decreased concentration may occur, thus driving or operating hazardous machinery should be avoided during treatment with this medication. Using this medication with other central nervous system depressants can enhance the effects and increase the risk of side effects, so caution is advised when co-administering. It is recommended to avoid administration in early pregnancy or to women of childbearing age, and lactating women should discontinue breastfeeding if necessary. Safety in pediatric patients under 18 years has not been established, and elders have a higher risk of side effects, so treatment should start with a low dose and proceed cautiously. In case of overdose, professional treatment is required, and care should be taken during intravenous administration methods and should not be mixed with other medications.

• Mental and physical dependence on drugs
• seizures
• delirium
• tremors
• insomnia
• anxiety
• hallucinations
• delusions
• agitation
• excitement

This medication is sensitive to light, so it should be stored in a container protected from light. Additionally, to maintain its effectiveness, it should be stored at refrigerated temperatures between 2 to 8 degrees.

Appearance

An injection in a brown ampoule containing a colorless and transparent liquid

Package unit

50 ampoules/box[(1mL/ampoule)×50], 50 ampoules/box[(0.5mL/ampoule)x50]