Ropain Capsule (Loperamide Hydrochloride)

Key information summary

Efficacy & effects

This medication is used to relieve various forms of diarrhea symptoms, such as acute diarrhea and chronic diarrhea.

Dosage

Acute diarrhea: The initial dose of loperamide hydrochloride is 4 mg administered orally, followed by a maintenance dose of 2 mg with each loose stool. The usual daily dose is 6-8 mg, and the maximum daily dose is 16 mg. Chronic diarrhea: The initial dose of loperamide hydrochloride is 4 mg administered orally, followed by 2 mg with each loose stool until diarrhea is resolved. After that, adjust according to individual patient needs.

Precautions

This medication should not be used in infants under 24 months or in children with chronic diarrhea. It should not be administered to patients with bacterial diarrhea accompanied by blood in the stool or high fever, patients with acute ulcerative colitis, or patients with serious gastrointestinal conditions such as intestinal obstruction or megacolon. If constipation or abdominal distension occurs, the medication should be discontinued immediately, and it should also not be used by patients with an allergy to this medication. Individuals with hereditary lactose intolerance or glucose-galactose malabsorption should not take this medication. Patients with poor liver function should use this medication cautiously, and fatigue, dizziness, or drowsiness may occur during administration, so caution is advised when driving or operating machinery. If diarrhea symptoms do not improve within 48 hours (acute) or 10 days (chronic), discontinue the medication and consult a doctor or pharmacist. Since diarrhea can result in loss of fluids and electrolytes, particularly children require appropriate fluid and electrolyte replenishment. Pregnant women in early pregnancy should carefully consider the benefits and risks of taking this medication, and breastfeeding women are advised against its use as it may be secreted in small amounts into breast milk. Children aged over 24 months to under 7 years must take this medication under the guidance of a doctor or pharmacist, and caution is needed due to the risk of overdose related to immature liver function. Elderly individuals may have decreased bodily functions, so dosage adjustment and caution are necessary. Overdose may result in central nervous system depression symptoms, urinary retention, and intestinal obstruction, so the prescribed dose should not be exceeded, and an antidote may be administered if necessary. This medication does not treat the underlying cause of diarrhea but alleviates symptoms; therefore, if symptoms do not improve, consult a healthcare professional.

Side effects

Urticaria, angioedema, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome (vesicular rash), anaphylactic shock and anaphylactic reactions (severe allergic reactions), intestinal obstruction, abdominal distension, toxic megacolon, urinary retention, respiratory depression, central nervous system depression (somnolence, miosis, muscle rigidity, coma, coordination movement failure), QT interval prolongation, serious ventricular arrhythmias

Interactions

This medication should be discussed with a doctor or pharmacist when taken with quinidine or ritonavir.

Alternatives / Same-ingredient medications

• 

  Geloferamide Hydrochloride Capsule

  Same ingredient
• 

  Samnam Loperamide Capsule (Loperamide Hydrochloride)

  Same ingredient
• 

  Roperi Capsule (Loperamide Hydrochloride)

  Same ingredient
• 

  Ropes Tab Capsule (Loperamide Hydrochloride)

  Same ingredient

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