International Cimetidine Tablets

Adult dose

For cimetidine, take 400 mg orally twice daily (in the morning and at bedtime) or 800 mg orally once daily (at bedtime). Additionally, 300 mg can be administered orally four times daily (after meals and at bedtime). The dose may be increased to 400 mg four times daily (after meals and at bedtime) for a total of 1.6 g. However, to improve gastric mucosal lesions (erosions, bleeding, redness, swelling) in the following conditions: acute gastritis, exacerbations of chronic gastritis.

Child dose

Administer 20-40 mg per kg of body weight daily in divided oral doses.

When using the glass ampoule injection, great care must be taken as glass fragments may mix in when cutting the container. Extra caution is particularly necessary when used for children or the elderly. Patients who have hypersensitivity to this medication or a history thereof, patients taking dofetilide, and those with lactose intolerance or related genetic disorders should not take this medication. Patients with impaired kidney or liver function, those with a history of drug hypersensitivity, the elderly, children under 19 years old, and patients undergoing hemodialysis should use this medication with caution. This medication can mask the symptoms of gastric cancer, so it should be administered only after confirming that it is not malignant, and patients with Helicobacter pylori infection require bacterial eradication therapy. Various side effects may occur, including hematological disorders, liver dysfunction, kidney impairment, hypersensitivity reactions, endocrine and gastrointestinal symptoms, neurological issues, and skin reactions; therefore, immediate consultation with healthcare professionals is necessary upon symptom onset. Blood tests may be required, and in severe cases, discontinuation of administration may be necessary. This medication interacts with many other drugs, so when taken with warfarin, midazolam, diazepam, propranolol, or multiple other medications, dosage adjustments or drug holidays may be needed. Women who are pregnant or could become pregnant should carefully weigh the benefits and risks of this medication, and nursing mothers should discontinue breastfeeding while using it. In children and the elderly, the blood concentration may increase due to decreased kidney function, necessitating dosage adjustments and extended intervals between doses. In cases of overdose, serious side effects such as respiratory depression may occur, requiring immediate emergency treatment. When used as an injection, rapid intravenous injection should be avoided, and it should be administered slowly to reduce the risk of side effects. This medication should be stored out of the reach of children, and changing the container is not advisable due to quality maintenance.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, diffuse rash, dyspnea, shock, anaphylactic-like reactions, severe rashes with high fever, blisters, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), epidermal necrosis, erythema multiforme, exfoliative dermatitis, generalized exfoliative erythroderma, skin or eyes turning yellow (jaundice),

Mild side effects

• Fatigue
• fever
• generalized heat sensation
• urinary difficulties
• myalgia
• arthralgia
• pancreatitis
• hair loss
• gynecomastia
• galactorrhea

This medication should be stored in a sealed container to prevent exposure to air or light. This prevents the degradation of the active ingredients and ensures safe use.

Appearance

Blue film-coated tablet

Package unit

100 tablets/bottle