Empagliflozin 2L-Proline/Metformin 12.5/500 mg Tablet

Adult dose

The recommended dosage is 1 tablet at a time, twice a day. The maximum recommended daily dosage for each ingredient is 25 mg of Empagliflozin and 2000 mg of Metformin. If a patient cannot achieve sufficient blood sugar control with Metformin alone or in combination with other medications like insulin, the recommended dosage is 5 mg of Empagliflozin twice a day (a total of 10 mg daily) along with the current dose of Metformin. The tolerance is excellent.

This medication can cause a rare side effect called severe lactic acidosis, so it should be used with caution, especially in patients with impaired kidney function, heart disease, or liver disease. When used in combination with other diabetes medications, hypoglycemic symptoms may occur, so blood sugar levels should be closely monitored. This medication should not be used in patients with moderate or severe renal impairment or in cases where acute kidney injury is suspected. It may be temporarily discontinued when a patient is in an unstable state, such as during acute infections, dehydration, severe trauma, or around surgery. Pregnant women or those who may become pregnant, and nursing mothers are advised not to take this medication. Elderly patients should have their kidney function regularly monitored due to a higher risk of renal impairment. This medication may increase the risk of urinary tract infections and genital infections, so medical consultation should be sought immediately in case of infection symptoms. Patients with dehydration or low blood pressure should be particularly cautious, as this medication may cause fluid loss; it may be temporarily discontinued if necessary. Vitamin B12 deficiency may occur, so those on long-term treatment should regularly check their vitamin B12 levels. It is important to avoid alcohol while taking this medication. If sudden fatigue, muscle pain, or breathing difficulties occur, visit the hospital immediately. Additionally, as this medication can affect blood sugar control, blood sugar levels should be checked regularly, and dosages should be adjusted as instructed by a healthcare provider. Before surgery or tests that involve contrast agents, this medication should be discontinued and resumed only after kidney function has returned to normal. During treatment with this medication, symptoms of hypoglycemia, lactic acidosis, and ketoacidosis should be carefully monitored, and any abnormal symptoms should be reported to healthcare professionals immediately.

Serious side effects

• Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reaction
• Severe rash with fever, blisters, skin peeling, mucosal pain in the mouth/eyes, severe skin adverse reactions
• Difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever
• Jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice)
• Sudden and severe headache

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to prevent exposure to air and should be kept at room temperature between 1 to 30 degrees Celsius. Proper storage maintains the medication's effectiveness for a longer period.

Appearance

Pale purple oval film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/bottle