Adrality Patch 10mg/day (Donepezil Hydrochloride Monohydrate)

Adult dose

The recommended starting dose of this medication is 5mg per day, and can be increased to a maximum of 10mg per day after 4 to 6 weeks. Apply 1 patch to the skin once a week. After 7 days, remove the used patch and apply a new patch, applying only 1 patch at a time. The recommended application site is the back (avoiding the spine), and the upper outer thigh or the upper part of the buttocks can be used if necessary. The patch

This medication is a transdermal patch containing donepezil hydrochloride, used for the treatment of symptoms of Alzheimer's dementia. This medication should not be used in patients with an allergy to donepezil, piperidine derivatives, or any components of the medication, as well as in pregnant women or those who may become pregnant, and nursing mothers. Patients with heart disease or cardiac conduction disorders should use this medication cautiously as it may stimulate the vagus nerve, causing bradycardia or arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be careful as gastric acid secretion and gastrointestinal motility may be enhanced, worsening symptoms. Patients with asthma or obstructive pulmonary diseases may experience exacerbation of symptoms due to bronchoconstriction and increased mucus secretion, so caution is advised. Patients with extrapyramidal disorders such as Parkinson's disease may have an increased risk of symptom worsening due to the cholinergic nerve stimulation of this medication. Serious side effects reported include syncope, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death. If symptoms occur, discontinue use immediately and consult a healthcare professional. Common side effects may include headache, dizziness, nausea, vomiting, diarrhea, insomnia, muscle cramps, rash, fatigue, anxiety, hallucinations, etc. This medication is approved for use only in patients with Alzheimer's dementia and should not be used for other types of dementia or memory disorders. During treatment, regular monitoring of heart condition is required, and gastrointestinal symptoms or skin reactions should also be closely observed. Caution is needed when driving or operating machinery, as dizziness or fatigue may occur. Pregnant or nursing women are advised against using this medication, and professional consultation is essential if absolutely necessary. Since this medication is metabolized by specific liver enzymes, drug interactions may occur with concurrent use, so it is crucial to inform healthcare providers about any other medications being taken. In case of overdose, serious symptoms such as nausea, vomiting, severe bradycardia, hypotension, respiratory suppression, and seizures may appear, and emergency treatment is required. Apply the patch to clean and dry skin, and avoid repeating the application to the same area. Change it every 7 days. After use, wash hands thoroughly and be careful not to rub eyes with hands that touched the patch. Store in a refrigerator (2-8 degrees Celsius) in a special container that does not allow light to enter, and keep sealed until use.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, gastrointestinal bleeding, peptic ulcers, perforated duodenal perforation, hepatitis, liver dysfunction, jaundice, cerebral seizure, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (motor function disorders, ataxia, dystonia, tremor, involuntary movement, gait disturbance, speech disorders), neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, cause

Mild side effects

• Headache
• dizziness
• diarrhea
• nausea
• vomiting
• insomnia
• muscle cramps
• fatigue
• constipation
• rash

This medication is sensitive to light, so it must be stored in a special container that prevents light entry. It is also important to store it at a refrigeration temperature between 2 and 8 degrees Celsius to maintain its efficacy.

Appearance

A transdermal patch consisting of a blue-colored release liner and a white to cream-colored support with a brownish-yellow embossed rectangular covering with rounded corners.

Package unit

4 sheets/box [(1 sheet/pack X 4)]