Mireadivalproate Extended-release Tablets 500 mg (Sodium Divalproate)

Adult dose

This medication is intended for once daily administration and should be swallowed whole without breaking or chewing the tablets. For seizure treatment, it is usable in children over 10 years and adults, with an initial dose of 10 to 15 mg per kg of body weight, increasing weekly by 5 to 10 mg according to optimal clinical response. The recommended final dose is 60 mg or less per kg of body weight per day. For migraine prevention, 500 mg once daily for one week is given followed by 1

Child dose

Can be administered to children over 10 years. The initial dosage is 10 to 15 mg per kg of body weight, increased weekly by 5 to 10 mg according to optimal clinical response. The final dosage is 60 mg per kg of body weight per day.

This medication requires special caution in pregnant women or women of childbearing potential, and strict adherence to pregnancy prevention programs is necessary. Even if the patient is not pregnant, this medication should not be administered to patients with impaired liver function or pancreatic issues. Regular liver function and blood tests should be performed during the course of this medication, especially during the first 6 months. This medication may increase the risk of suicidal thoughts or behaviors, so careful observation for mood changes or unusual behaviors is necessary during treatment. Additionally, this medication can cause serious side effects such as hepatotoxicity and pancreatitis; if abdominal pain, nausea, or vomiting occurs, immediate consultation with a healthcare professional is required. Thrombocytopenia may occur, so if there is a tendency to bleed or easy bruising, it should be reported immediately. This medication may interact with other drugs, so patients on carbapenem antibiotics or estrogen-containing preparations should definitely consult a physician. Elderly or pediatric patients require dosage adjustments and caution; sudden discontinuation may risk worsening seizures, so tapering should be gradual. Due to its central nervous system depressant effects, this medication may cause drowsiness, so it is advisable to avoid driving or operating hazardous machinery after taking it. Patients and caregivers should fully understand the side effects and cautions of this medication and promptly inform healthcare providers of any unusual symptoms.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination

Mild side effects

• Headache
• weakness
• fever
• nausea
• vomiting
• abdominal pain
• diarrhea
• loss of appetite
• dyspepsia
• constipation

This medication should be stored in a tightly closed container to prevent air or moisture entry and at a temperature between 1 degree to 30 degrees Celsius. This storage method helps maintain the medication's efficacy.

Appearance

Gray oval extended-release tablets

Package unit

30 tablets/bottle, 100 tablets/bottle