Sitafomin XR Controlled-release Tablet 50/1000 mg

Adult dose

This medication is to be taken once daily with dinner, gradually increasing the dose. The 100/1000 mg controlled-release tablet is taken once daily, 1 tablet per dose. Patients taking the 50/500 mg controlled-release tablet or the 50/1000 mg controlled-release tablet should take 1 dose of 2 tablets once daily. 1. Patients not currently receiving metformin: - The initial dose is once daily.

This medication contains two components: Sitagliptin and Metformin. Firstly, Sitagliptin helps to control blood sugar; however, it can occasionally cause serious allergic reactions or skin conditions, as well as pancreatitis, so symptoms should be closely monitored during use. Metformin is effective in lowering blood sugar, but it can be hazardous for patients with compromised kidney or liver function, potentially leading to a life-threatening condition known as lactic acidosis in severe cases. Therefore, this medication should not be administered to patients with moderate or severe renal impairment, acute heart failure, severe infections, dehydration, pregnant or breastfeeding women. Moreover, excessive alcohol consumption increases the risk of lactic acidosis, so alcohol should be avoided during treatment with this medication. During the course of taking this medication, regular kidney function and blood tests should be performed to monitor for abnormalities, and caution should be taken when experiencing irregular meals, intense exercise, or taking other medications, as there is a risk of hypoglycemia. If sudden respiratory difficulties, skin rash, swelling, severe abdominal pain, vomiting, or lethargy occur while taking this medication, immediate consultation with a doctor is recommended. If surgery is planned, this medication should be discontinued 48 hours beforehand and should not be resumed until kidney function has been confirmed as normal after the surgery. The safety and efficacy of this medication have not been established in children, and elderly patients should use it cautiously due to the risk of side effects associated with decreased kidney function. Hypoglycemic symptoms may occur, so especially when taken in combination with insulin or sulfonylureas, blood glucose levels should be monitored frequently, and symptoms should be carefully observed.

Serious side effects

• Hives
• severe swelling (edema)
• anaphylaxis
• angioedema
• rash
• cutaneous vasculitis
• Stevens-Johnson syndrome
• acute pancreatitis
• acute renal failure
• bullous pemphigoid

Mild side effects

Diarrhea, upper respiratory tract infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, joint pain associated with severe and disability.

This medication should be stored in a tightly closed container to prevent air and moisture infiltration. It is recommended to maintain a storage temperature between 1°C and 30°C to preserve the drug's efficacy over time.

Appearance

Bright green, oval-shaped controlled-release film-coated tablet with convex sides

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle