Depateriem Extended-Release Tablet 10/750 mg (Teneligliptin Hydrobromide Hydrate, Metformin Hydrochloride)

Adult dose

This medication is typically administered once daily with the evening meal, with the dosage adjusted gradually to reduce gastrointestinal side effects associated with metformin. For the 20/1000 mg extended-release tablet, the dosage is 1 tablet once daily. For the 10/750 mg or 10/500 mg extended-release tablets, the dosage is 2 tablets taken simultaneously once daily. The initial dosage provides 20 mg of teneligliptin once daily along with the current dosing schedule of metformin.

This medication is a diabetes treatment that helps control blood sugar. It is essential to ensure that kidney function is normal before using this medication. Patients with impaired kidney function or severe renal impairment should not use this medication. Additionally, patients with liver impairment, heart failure, acute myocardial infarction, severe infection, or traumatic conditions should avoid this medication. It is also advisable not to administer this medication to pregnant women or women who may become pregnant, as well as to patients who are malnourished or severely weakened. This medication can rarely cause a dangerous condition known as lactic acidosis, so if symptoms such as shortness of breath, muscle pain, abdominal pain, or weakness occur, it is vital to notify a doctor immediately. When used in conjunction with other diabetes medications or insulin, hypoglycemia may occur, hence patients should be aware of hypoglycemic symptoms and their management. Regular blood tests to monitor kidney function and vitamin B12 levels are essential while using this medication. If scheduled for tests using radioactive iodine contrast, this medication should be stopped 48 hours prior and resumed only after confirming normal kidney function following the tests. For patients undergoing major surgery, this medication should also be discontinued 48 hours before surgery, and should resume only after confirming kidney function recovery. Patients should avoid excessive alcohol intake while taking this medication, as alcohol may elevate the risk of side effects. If skin blisters or severe joint pain occur during the use of this medication, it is necessary to consult medical staff immediately, and discontinuation may be required. Elderly patients may experience decreased kidney function, thus requiring dosage adjustments and regular kidney function tests. During the course of taking this medication, it is critical to monitor for symptoms of hypoglycemia, lactic acidosis, and liver dysfunction, and to consult a doctor immediately if any abnormal symptoms appear.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosa pain, shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanied respiratory abnormalities, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, vision disturbances, paralysis, urination abnormalities

Mild side effects

• Hypoglycemia
• constipation
• dizziness
• abdominal bloating
• abdominal discomfort
• nausea
• abdominal pain
• flatulence
• stomatitis
• gastric polyps

This medication should be stored in a sealed container to prevent air entry, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the drug's effectiveness.

Appearance

Yellow oval-shaped extended-release film-coated tablet

Package unit

30 tablets/bottle