Daidian Tablet 10 mg (Empagliflozin)

Adult dose

The recommended dosage of this medication for monotherapy and additional combination therapy with insulin and other antidiabetic agents is 10 mg once daily. For cases where tolerance to this 10 mg dose is good but additional blood sugar control is needed, the dose may be increased to 25 mg once daily. When this medication is administered with sulfonylureas or insulin, dosage reductions of sulfonylureas or insulin should be considered to reduce the risk of hypoglycemia.

This medication should not be used in patients who are allergic to the active ingredient or any of its components. It should also not be administered to patients with type 1 diabetes or diabetic ketoacidosis. Patients with severely reduced kidney function, specifically those with a glomerular filtration rate of less than 30 mL/min/1.73m2 or those with end-stage renal disease or those on dialysis should not use this medication. This drug contains lactose, so it should not be given to patients with genetic issues such as lactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. It should be used with caution in patients with mild kidney impairment, and it is recommended not to initiate treatment if the glomerular filtration rate is below 60 mL/min/1.73m2. If kidney function continues to decline and falls below 45 mL/min/1.73m2, this medication should be discontinued. Caution should be exercised in patients with mild heart failure, and it is not recommended for severe heart failure patients. This drug may increase the risk of hypoglycemia when used with insulin or sulfonylureas, so dosage adjustments may be necessary when combined. While taking this medication, be alert for hypoglycemic symptoms, especially when used with insulin or sulfonylureas. Adverse effects such as genital infections, urinary tract infections, and increased urination may occur, so consult a healthcare provider immediately if symptoms arise. There may be a risk of lowered blood pressure or dehydration due to reduced fluid volume, so elderly patients or those taking blood pressure medications should be cautious. Severe metabolic disturbances such as ketoacidosis may occur rarely, so if symptoms such as nausea, vomiting, abdominal pain, or difficulty breathing arise, visit a hospital immediately. Pregnant women should avoid taking this medication, and if pregnancy is confirmed, they should discontinue use immediately. Breastfeeding women are also recommended to stop breastfeeding while taking this medication. Children under 18 years old should not use this medication as its safety and efficacy have not been established. No special toxicity has been reported in the case of overdose, but appropriate treatment based on clinical conditions is necessary. This medication should be kept out of reach of children and not transferred to another container as a safety measure. Caution is needed when driving or operating machinery due to the risk of hypoglycemia, especially when taken in conjunction with insulin or sulfonylureas. Patients with diabetes should pay attention to routine foot care, and since serious side effects such as limb amputation have been reported rarely, regular foot checks are advised. If there is pain, soreness, swelling, or fever in the perineal area, it may indicate the possibility of perineal necrosis, so inform a healthcare provider immediately and seek treatment.

Serious side effects

Urticaria, angioedema (severe swelling), ketoacidosis, urosepsis, pyelonephritis, perineal necrosis, rash (severe skin adverse reactions), headache (including sudden and very severe headache), cerebrovascular accident, intracranial aneurysm, liver damage (including yellowing of the skin or eyes), acute cholecystitis, autoimmune hepatitis, cholelithiasis, acute kidney injury, severe edema associated with high blood pressure and urinary abnormalities, heart failure, deep venous thrombosis,

Mild side effects

• Hypoglycemia
• vulvovaginal candidiasis
• balanitis and other genital infections
• increased urination
• urinary tract infections
• fluid volume loss
• increased serum creatinine
• decreased glomerular filtration rate
• rash
• itching

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Pale yellow, biconvex, round film-coated tablet

Package unit

30 tablets/bottle