Sitagliptin 50 mg Tablet (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This drug is administered at a dose of 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. For patients with renal impairment, a dose of 50 mg is administered once daily for moderate renal impairment (glomerular filtration rate 30–45 mL/min/1.73 m2). In cases of severe renal impairment (glomerular filtration rate 15–30 mL/min/1.73 m2) or end-stage renal disease requiring hemodialysis or peritoneal dialysis (glomerular filtration rate <

This medicine may cause severe hypersensitivity reactions after administration, so if allergic symptoms occur, discontinue use immediately. Consult a physician immediately if symptoms of pancreatitis appear while taking the medication, and discontinue use if necessary. Patients with type 1 diabetes or hypersensitivity to any component of this drug should not take it. Patients with decreased kidney function need to adjust the dosage, so consult a physician. When used in combination with other hypoglycemic agents, caution is needed due to the risk of hypoglycemia, and dosage adjustments of other medications may be necessary. Prolonged use may lead to adverse reactions such as arthralgia, skin rash, and blistering skin diseases, so inform a physician if symptoms occur. Pregnant or breastfeeding women are advised to avoid taking this medication. Elderly patients should undergo regular kidney function tests as kidney function may decline. In case of overdose, immediate medical attention is required, and some removal may be possible through hemodialysis. This drug has little effect on cardiovascular safety, but it is important to consult healthcare professionals if adverse reactions occur.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis (severe allergic reaction), rashes, skin peeling, mucosal pain in the mouth/eyes (such as Stevens-Johnson syndrome and other severe skin reactions), acute pancreatitis, acute renal failure, severe and disabling arthralgia, blistering dermatitis, shortness of breath or difficulty breathing, liver abnormalities (increased liver enzyme levels, possibility of jaundice), severe edema

Mild side effects

• Headache
• upper respiratory tract infection
• nasopharyngitis
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medicine should be stored in a tightly sealed container to prevent air or moisture from entering and should be kept at room temperature between 1 and 30 degrees Celsius. This helps maintain the efficacy of the drug and prevents degradation.

Appearance

A light apricot-colored, biconvex round film-coated tablet

Package unit

28 tablets/box [14 tablets/PTPX2]