Sitava Tablet 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The recommended dose is 100 mg once daily, either as monotherapy or as part of combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dose adjustment is necessary. - Mild renal impairment (eGFR 60-90 mL/min/1.73 m2): No dose adjustment needed. - Moderate renal impairment (eGFR 45-60 mL/min/1.73 m2):

This medication can rarely cause serious allergic reactions. Such reactions may appear within the first 3 months after starting the medication, so if symptoms like skin rash or difficulty breathing occur, it is important to stop taking the drug immediately and consult a doctor. This medication can cause a disease known as pancreatitis, which is inflammation of the pancreas, so if symptoms like abdominal pain or vomiting occur, alert healthcare personnel immediately. This medication should not be used in patients with type 1 diabetes, diabetic ketoacidosis, or those allergic to this drug or its components. Patients with impaired kidney function may require a dose adjustment, and it is important to undergo regular kidney function tests. During treatment with this medication, symptoms similar to a cold, headache, indigestion, diarrhea may occur. Additionally, symptoms of hypoglycemia may appear, especially when taken with insulin or sulfonylureas, so caution is needed. The risk of hypoglycemia may increase when this medication is taken with other hypoglycemic agents; therefore, adjusting the doses of other medications may be necessary. Rarely, symptoms like arthralgia or blisters on the skin have been reported, so if these symptoms appear, consult a physician immediately. This medication is not recommended for use during pregnancy or breastfeeding, and its safety for children under 18 years old has not been established. In cases of overdose, general supportive care and, if necessary, blood dialysis may be considered. This medication is known not to significantly affect cardiovascular safety; however, if any abnormal symptoms occur during treatment, consult a healthcare provider immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, severe hypersensitivity reactions (anaphylaxis), severe skin reactions (Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, worsening kidney function (acute renal failure), severe joint pain with disability, bullous pemphigoid, severe allergic reactions, significant swelling, liver abnormalities (elevated liver enzymes), angioedema, severe neurological symptoms (including cardiac arrest)

Mild side effects

• Headache
• upper respiratory infection
• nasopharyngitis
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• pruritus
• myalgia

This medication should be stored in a tightly closed container to protect it from air or moisture, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication for a longer time.

Appearance

Pink, round, double convex film-coated tablet

Package unit

28 tablets) 14 tablets/PTP(x2), 30 tablets) 10 tablets/PTP(x3)