Atradol Semi Tablet

Adult dose

Children aged 12 and older and adults: Dosage is adjusted based on the patient's level of pain and treatment response. A loading dose of four tablets is recommended, followed by administration at intervals of at least 6 hours, with a maximum of 16 tablets per day. Administer for the shortest duration possible at the effective minimum dose. Do not administer this medication for longer than necessary; if prolonged use is required due to the nature and severity of the disease, regular monitoring should be conducted to confirm the continued administration of this medication. Elderly patients: Administer the typical adult dose. However, for elderly patients aged 75 and older, the elimination half-life of tramadol increases by 17% when taken orally, therefore administer at least 6 hours apart. Renal impairment: For patients with moderate renal impairment (creatinine clearance of 10-30 ml/min), the administration interval should be extended to 12 hours. Severe renal impairment patients (creatinine clearance below 10 ml/min) are not recommended for administration. Tramadol is removed very slowly during blood dialysis and filtration; therefore, it is unnecessary to re-administer this drug after dialysis to maintain its analgesic effect. Liver failure patients: For patients with moderate liver failure, it should be administered with an extended interval cautiously. For patients with severe liver failure, administration of this medication is contraindicated.

Child dose

Children aged 12 and older and adults: Dosage is adjusted based on the patient's level of pain and treatment response. A loading dose of four tablets is recommended, followed by administration at intervals of at least 6 hours, with a maximum of 16 tablets per day.

This medication can burden the liver, so those who regularly consume more than three drinks a day must consult a doctor or pharmacist before taking it. Since this medication contains acetaminophen, severe skin reactions may occur rarely; discontinue use immediately if skin rash or hypersensitivity occurs. Due to the tramadol component, there is a risk of seizures, so caution is needed for those with a history of seizures or risk factors for seizures. Particularly, taking it with certain antidepressants or narcotics may increase seizure risk, so consultation with a specialist is essential. This medication can rarely cause life-threatening allergic reactions, so if allergic symptoms occur, immediate medical attention is required. For patients with severe bronchial asthma, careful observation is necessary due to the risk of respiratory depression; alternative analgesics should be considered if possible. Taking it with alcohol or benzodiazepines may lead to severe sedation and respiratory depression, thus should be used at minimal doses for the shortest duration. Patients with head trauma or elevated intracranial pressure should be cautious as this medication's respiratory depressant effect may worsen their condition. This medication may lead to psychological and physical dependence; thus, the possibility of dependence should be considered if used for a long period. Patients with impaired liver function should consult a doctor before taking it due to the risk of liver damage from acetaminophen. Some patients with rapid drug metabolism may experience excessive effects from the active ingredients, leading to a high risk of severe respiratory depression, requiring special caution. This medication should not be administered to children under 12 years old or adolescents under 18 years old who have undergone tonsillectomy or adenoidectomy. Patients with sleep apnea or hypoxia may experience worsening symptoms after taking this medication; therefore, continuous evaluation and dosage adjustment may be necessary. Elderly patients or those at risk of hyponatremia may experience hyponatremia, necessitating monitoring through blood tests. Those with hypersensitivity or those taking certain medications concurrently should not use this medication, and special caution is needed when taken with central nervous system depressants. Pregnant or breastfeeding women should consult a doctor as this medication may pose risks to the fetus or newborn. Drowsiness or dizziness may occur during use, requiring caution while driving or operating machinery. In case of overdose, there is a risk of severe respiratory depression, seizures, liver damage, etc.; thus, the specified dosage must be strictly followed, and in emergencies, seek immediate medical attention. This medication should be stored out of reach of children to prevent misuse or accidental ingestion.

Serious side effects

• Hives
• hypersensitivity
• anaphylaxis
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• seizures
• severe swelling (edema)
• chest tightness
• difficulty breathing
• cold sweat

Mild side effects

• Loss of appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

Store this medication in a sealed container that prevents air from entering, ideally at room temperature between 1 to 30 degrees Celsius. This helps maintain the medication's effectiveness.

Appearance

Light yellow, oblong, film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle, 500 tablets/bottle