SimbaDuet Tablets 10/20mg

Adult dose

This medication is taken once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dose range is from 10/10mg to 10/40mg once daily, with the generally recommended starting dose being 10/20mg daily. Patients with less need for LDL cholesterol reduction may begin with a dose of 10/10mg daily. After verifying lipid levels at intervals of more than 4 weeks, the dosage may be adjusted. For homozygous familial hypercholesterolemia patients, the recommended dose is 10/40mg taken once daily in the evening. This medication is administered as an adjunct to other lipid-lowering treatments (e.g., LDL Apheresis) or when other lipid-lowering treatments are not effective. In patients with liver impairment, mild cases may not require dose adjustments, but moderate to severe liver impairment patients are advised against taking this medication (see precautions for patients with liver dysfunction). For patients with renal impairment accompanying chronic kidney disease, those with mild renal impairment (estimated glomerular filtration rate (GFR) ≥ 60mL/min/1.73㎡) do not need dose adjustments. For patients accompanying chronic kidney disease and estimated GFR < 60mL/min/1.73㎡, 10/20mg should be taken once daily in the evening. Careful administration and monitoring of these patients is necessary when considering higher doses (see precautions for general cautions). For the elderly, dose adjustments are unnecessary.

This medication is used to lower blood cholesterol levels. When taking this medication, one must be careful as symptoms such as muscle pain or weakness may occur. Immediate consultation with a physician is necessary if any muscle-related unusual symptoms arise. Patients with poor liver function or liver disease should not take this medication. Regular liver function tests are recommended. Women who are pregnant or breastfeeding should not use this medication. Women planning to become pregnant should consult a physician before taking this medication. Interactions with other medications may occur, so it is essential to inform healthcare providers of any current medications being taken. In particular, the risk of muscle-related side effects may increase when combined with certain antibiotics, antifungals, antivirals, and some cardiac drugs. Elderly patients, those with impaired kidney function, and patients with hypothyroidism should be more cautious when using this medication, and regular monitoring is needed. It is advised not to excessively consume grapefruit juice or grapefruit while on this medication as grapefruit can increase the blood concentration of this medication, raising the risk of side effects. This medication may slightly elevate blood sugar levels, so individuals at risk of diabetes should manage their blood sugar accordingly. Always consult a physician before changing or discontinuing dosage, and in case of overdose, seek medical treatment immediately.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory distress accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme malaise, sudden severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Headache, diarrhea, influenza, upper respiratory tract infection, muscle pain, limb pain, fatigue, nausea, abdominal pain, constipation, dyspepsia, flatulence, itching, rash, joint pain, back pain, cough, dizziness, paresthesia, depression, weakness, insomnia, increased serum creatine phosphokinase (CPK), weight loss, edema, thirst, facial swelling, syncope, sensory loss, gastritis, atrophic gastritis, mucus stool, irritable bowel syndrome, sore throat, nocturia,

This medication is sensitive to air and moisture; therefore, it should be stored in a tightly closed container. Additionally, to maintain its effectiveness, it is important to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

White to off-white, bilaterally convex, rectangular tablet

Package unit

30 tablets/box [30 tablets (10 tablets/PTP*3)]