Atmaset Tablets

Adult dose

For children over the age of 12 and adults: Dosage should be adjusted according to the patient’s pain level and therapeutic response. A starting dose of 2 tablets is recommended, and thereafter dosages should be spaced at least 6 hours apart, but not exceed 8 tablets in one day. Administer the lowest effective dose for the shortest period possible. Avoid long-term use of this medication beyond necessity, and if prolonged use is needed due to the nature and severity of the illness, regular monitoring should be conducted to assess whether continuing administration of this medication is necessary. Elderly Administer a typical adult dose. However, for elderly patients over 75 years old, the elimination half-life of tramadol increases by 17% when administered orally, so the dosing should be spaced at least 6 hours apart. Renal Impairment For those with moderate renal impairment (creatinine clearance of 10-30 ml/min), extend the dosing interval to 12 hours. For those with severe renal impairment (creatinine clearance below 10 ml/min), administration is not recommended. Tramadol is very slowly removed by hemodialysis and filtration, so there is no need to re-administer this medication to maintain its analgesic effect post-dialysis. Hepatic Impairment For patients with moderate hepatic impairment, careful consideration should be given to extend the dosing interval. Do not administer this medication to patients with severe hepatic impairment.

Child dose

For children over the age of 12 and adults: Dosage should be adjusted according to the patient’s pain level and therapeutic response. A starting dose of 2 tablets is recommended, and thereafter dosages should be spaced at least 6 hours apart, but not exceed 8 tablets in one day.

This medication can lead to liver damage for those who regularly drink more than three glasses of alcohol daily, so it is essential to consult a doctor or pharmacist. If serious skin reactions, such as rash or blisters, appear while taking this medication, discontinue use immediately and consult medical personnel. One of the ingredients in this medication, tramadol, may increase the risk of seizures if the recommended dose is exceeded, and this risk may be higher if taken in conjunction with certain antidepressants or other narcotic analgesics. Rarely, serious allergic reactions such as anaphylaxis may occur, so immediate treatment is necessary if unusual symptoms appear. Patients with acute and severe bronchial asthma are at risk of significant respiratory suppression from taking this medication, thus it should be administered under monitoring in a medical facility. Combining this medication with alcohol or benzodiazepines can lead to severe drowsiness, respiratory suppression, and coma, so it should be avoided. Patients with head injuries or increased intracranial pressure should be cautious, as carbon dioxide build-up due to this medication may worsen their condition. This medication, like morphine-type analgesics, can cause psychological and physical dependence, so long-term use should be closely monitored for signs of addiction. The acetaminophen ingredient is metabolized in the liver, so patients with decreased liver function must consult a doctor before taking this medication, and care should be taken not to exceed a total daily dosage of 4,000 mg. Patients with faster metabolism of the active ingredient due to genetic factors may experience an increased risk of respiratory suppression, necessitating dosage adjustment and monitoring. Children under 12 years old and those under 18 years old who have had tonsillectomy or adenoidectomy should not receive this medication, and use in children aged 12 to 18 should be avoided if there is a risk of respiratory suppression. This medication may cause sleep apnea or hypoxia, so continuous observation for these symptoms is necessary, with dosage reduction or discontinuation as needed. Elderly patients or those at risk of hyponatremia should be carefully monitored for symptoms of hyponatremia while taking this medication. This medication should not be given to certain patients, such as those allergic to any of its components, those in severe respiratory suppression, head injury patients, those taking MAO inhibitors, those with severe liver or kidney impairment, nursing mothers, and children under 12. Do not exceed the recommended dose while taking, and avoid taking with other tramadol or acetaminophen products. Abrupt discontinuation can lead to withdrawal symptoms such as anxiety, sweating, insomnia, and tremors, so it is advisable to taper off gradually under a doctor's supervision. Caution is required when combining this medication with other CNS depressants or alcohol, as it can lead to severe sedation and respiratory suppression. Drowsiness or dizziness may occur while driving or operating machinery, so caution is advised. In cases of overdose, severe symptoms such as respiratory suppression, seizures, and liver damage may occur, necessitating immediate emergency treatment and, if necessary, administration of an antidote. This medication should be stored out of reach of children and taken according to a doctor’s prescription and direction.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attack, respiratory issues coupled with cough and fever, breathing difficulties, yellowing of the skin or eyes (jaundice), profound lethargy, liver anomalies (jaundice), sudden and

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This medication should be stored in a tightly sealed container to prevent air or moisture ingress, ideally in a cool place below room temperature (25 degrees Celsius).

Appearance

Pale yellow oblong film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle