Ezetimibe/Simvastatin Tablets 10/20

Adult dose

This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dosage range is 10/10mg to 10/40mg per day. The generally recommended initial dose is 10/20mg once daily. Patients with a lower need for LDL cholesterol reduction may start at 10/10mg per day. After initiation or dose adjustment, blood lipid levels should be checked at intervals of more than 4 weeks.

This medication has the potential to cause muscle disorders such as myopathy or rhabdomyolysis. The risk may be increased when taken in high doses or with certain medications, so caution is required. Patients with allergies to any ingredients in this medication or severe liver dysfunction, as well as pregnant or breastfeeding women, should not take this drug. Additionally, this medication can affect liver function, so patients with liver disease should always consult a doctor before taking it. If unexplained muscle pain or weakness occurs during use, it should be reported to a doctor immediately. This drug can interact with other medications, so patients should inform their healthcare providers of any other medications they are currently taking. Particularly, taking it with drugs that inhibit the enzymes that metabolize this drug in the liver may increase the risk of side effects. Women who are planning to become pregnant or are of childbearing potential should consult a doctor before taking this drug and stop the medication immediately if pregnancy is confirmed. During breastfeeding, as this drug may be excreted in breast milk, it is advised to discontinue breastfeeding. Caution is needed in elderly patients and children as safety and effectiveness have not been sufficiently confirmed. Regular blood tests to monitor liver function and muscle-related indicators are recommended. There is no specific antidote in case of overdose, and symptomatic treatment will be provided based on the symptoms. It is also safe to limit the intake of certain foods such as grapefruit juice while taking this drug.

Serious side effects

Urticaria, angioedema and rash, pancreatitis, cholelithiasis, cholecystitis, anaphylaxis, erythema multiforme-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, positive antinuclear antibodies, increased erythrocyte sedimentation rate, eosinophilia, arthritis, urticaria, fever, chills, flushing, malaise, difficulty breathing, toxic epidermal necrolysis (Lyell's syndrome), mucocutaneous syndrome (Stevens-Johnson syndrome).

Mild side effects

Headache, diarrhea, influenza, upper respiratory tract infection, myalgia, limb pain, fatigue, abdominal pain, nausea, constipation, dyspepsia, flatulence, pruritus, rash, pharyngitis, sinusitis, arthralgia, low back pain, cough, weakness, cataracts, elevated laboratory values (ALT, AST, creatine kinase, etc.), insomnia, dizziness, sensory disturbances, peripheral neuropathy, mental disorders, anxiety, sleeping disorders, depression, respiratory abnormalities, hair loss.

This medication should be stored tightly sealed to prevent exposure to air or moisture. It is also safe to store at room temperature, that is, between 1 degree and 30 degrees Celsius, avoiding extreme heat or cold.

Appearance

White to pale white, biconvex, rectangular tablet

Package unit

30 tablets/PTP [(10 tablets/PTP X 3)]