Ezetimibe/Simvastatin Tablets 10/10

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, with the commonly recommended initial dosage being 10/20 mg per day. Patients who need less reduction in LDL-cholesterol can start with 10/10 mg per day. The recommended dosage for patients with homozygous familial hypercholesterolemia is 10/40 mg per day.

This medication may cause muscle-related side effects such as myopathy or rhabdomyolysis. The risk of these side effects increases as the dosage of the drug rises, making caution particularly necessary when taking high doses. If symptoms such as muscle pain, muscle weakness, or unexplained muscular pain occur, inform your doctor immediately. Additionally, this drug may affect liver function; therefore, it should not be administered to patients with liver disease or elevated liver enzyme levels. Pregnant or nursing women should not take this medication, and women of childbearing age should consult a physician before use. This drug may interact with certain medications to increase the risk of myopathy, so inform your healthcare provider of any other medications you are taking. Caution is needed especially when used in combination with strong CYP3A4 inhibitors, fibrates, certain antibiotics, and anticoagulants. Elderly patients and those with hypothyroidism or renal impairment should be carefully observed while taking this medication. Regular blood tests are recommended to monitor liver function and muscle enzyme levels during treatment. Additionally, if a new medication is started while on this drug, inform your healthcare provider that you are currently taking it. In case of overdose, there is no specific antidote available, so immediate medical attention should be sought. This medication has not been adequately studied for safety and efficacy in children and adolescents, thus should be used cautiously and according to a doctor's instructions if necessary.

Serious side effects

Hives, angioedema and rash (allergic reactions), pancreatitis, cholelithiasis, cholecystitis, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, severe allergic reactions, severe skin abnormal reactions, severe abnormalities of skin and mucous membranes, hepatitis (including chronic active hepatitis), cholestatic jaundice, cirrhosis, fulminant hepatic necrosis, liver cancer, liver failure, jaundice (yellowing of skin or eyes), gynecomastia, anemia, myopathy

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory infection
• muscle pain
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius. This ensures that the effectiveness of the medication is preserved and prevents deterioration.

Appearance

White to pale yellow, biconvex, rectangular tablet

Package unit

- - 30 tablets/PPT [10 tablets/Alu-Alu×3]