Uniserein Capsule (Diacerein)

Adult dose

Adults: Administer 50∼100mg of diacerein orally in 1∼2 divided doses daily after meals. Adjust the dose appropriately according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with inflammatory bowel disease. Patients with bowel obstruction syndrome or unexplained abdominal pain should also avoid taking this medication. Additionally, patients who had allergic reactions to this medication or its ingredients, those with liver disease or a history of liver disease, and children under 15 years of age should not take this medication. Patients with a history of small intestine or colon disease should use this medication cautiously, and pregnant or breastfeeding women should also be careful when taking this medication. For elderly patients over 65 years of age, it may be necessary to reduce the dosage. When taking this medication, gastrointestinal symptoms such as diarrhea, loose stools, and abdominal pain may occur. Prolonged use may lead to serious gastrointestinal complications such as gastric bleeding, ulcers, and perforation; therefore, caution is required. Rarely, there may also be pigmentation of the rectal mucosa. If diarrhea is severe, dehydration and electrolyte imbalance may occur; if these symptoms appear, discontinue the medication immediately and consult a physician. Skin reactions such as itching, rash, and eczema may also frequently occur. Since there may be an impact on liver function, increases in liver enzyme levels are not uncommon. Long-term use should strictly follow the physician's instructions, and if diarrhea is severe, the use of this medication should be discontinued, following the directions of healthcare professionals. It is advised to avoid taking it with laxatives. Careful observation for signs of liver damage is required, especially when combining this medication with other drugs that may put a burden on the liver. It is also advisable to limit alcohol consumption while taking this medication. If there is an increase in liver enzymes or signs of liver damage, discontinue the medication immediately and seek medical attention. Taking this medication with antacids containing calcium, magnesium, or aluminum, or with salt may interfere with its absorption, so it is recommended to space out the doses by more than 2 hours. Taking it with diuretics may enhance diuretic effects, thus posing a risk of dehydration and hypokalemia; caution is required. Furthermore, taking it with heart medications like cardiac glycosides may increase the risk of arrhythmias, so be careful. Pregnant women should avoid taking this medication as it may affect fetal bone formation, and breastfeeding women should also avoid it since the medication can be transmitted through breast milk.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, increased serum liver enzymes

Store this medication in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

A hard capsule filled with a brownish-yellow content, white on the top and yellow on the bottom.

Package unit

30 capsules/bottle, 500 capsules/bottle