Mepril M Tablet 2/500mg (Glimepiride, Metformin Hydrochloride)

Adult dose

This medication is administered 1 to 2 times a day before or with meals. Treatment usually starts at a lower dose and can be adjusted based on the patient's current medications and blood sugar levels. In clinical trials, the initial daily dosage was Glimepiride/Metformin Hydrochloride 2mg/500mg, with gradual increase according to blood sugar monitoring results up to Glimepiride/Metformin Hydrochloride 8mg/2000mg.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, it should be discontinued if there is acute decline in kidney function. If symptoms of dehydration occur, it is advisable to temporarily stop this medication and consult a physician. Caution is necessary when used with certain medications that may affect kidney function, and excessive alcohol consumption should be avoided. Patients with insulin-dependent diabetes, acute metabolic acidosis, severe hepatic or renal dysfunction should not use this medication. It is safe for pregnant or breastfeeding women to avoid using this medication. During the initial stages of treatment, the risk of hypoglycemia is high, so regular meal intake and careful monitoring of hypoglycemic symptoms are necessary. Gastrointestinal disturbances may occur while taking this medication; if symptoms are severe, consult a physician. If allergic reactions occur, notify medical personnel immediately. Rarely, blood abnormalities or liver function abnormalities may occur, so regular examinations are necessary. This medication may decrease vitamin B12 levels, so regular blood tests are recommended with long-term use. Overdosage may lead to hypoglycemia or lactic acidosis; therefore, strict adherence to the dosage is essential, and immediate medical attention is required if any abnormal symptoms occur. Regular checks of blood sugar control are necessary, and inform your healthcare provider of all medications being taken due to potential interactions. Extra caution is needed when driving or operating machinery due to the risk of hypoglycemia or dizziness. Children and elderly individuals may require dosage adjustments and close monitoring of kidney function, with regular kidney examinations especially recommended for the elderly. This medication has not been sufficiently proven safe and effective for children, so caution is advised in its use.

Serious side effects

• Hives
• severe swelling (edema)
• shortness of breath
• severe allergic reactions
• lactic acidosis
• hypoglycemia
• difficulty breathing
• severe skin reactions
• liver issues (jaundice)
• severe edema or urination abnormalities

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• weakness
• drowsiness
• sleep disorders
• instability

This medication should be stored in a sealed container to prevent air or moisture from entering. It is advisable to keep the storage temperature between 1 to 30 degrees Celsius. Storing it this way can prolong the medication's effectiveness.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle