Acepen Premix Injection (Acetaminophen)

Adult administration

Adults weighing 50 kg or more may receive 1000 mg of acetaminophen intravenously, with a minimum dosing interval of 4 hours, not exceeding a total of 4 grams per day. For children weighing 33 kg or more and adults below 50 kg, administer acetaminophen intravenously at approximately 15 mg/kg (about 1.5 mL/kg) with a minimum dosing interval of 4 hours. The maximum daily dose.

Child administration

For children weighing 33 kg (approximately 11 years) and above, administer acetaminophen intravenously at approximately 15 mg/kg (about 1.5 mL/kg) with a minimum dosing interval of 4 hours. The maximum daily dose is 6.

Caution should be taken not to confuse milligrams and milliliters during administration. Confusion in units can lead to serious intoxication or even death in case of overdose. It is advisable to switch to an appropriate analgesic as soon as oral administration is possible. Always verify whether acetaminophen is included in other medications to avoid excessive dosing. This drug can put stress on the liver, so it should not exceed the recommended dosage, and symptoms of liver damage may appear between 2 to 6 days after administration. If liver damage is suspected, immediate detoxification treatment is required, and patients with liver disorders should take it only after consulting with a physician. Individuals who frequently drink alcohol should consult with healthcare providers before taking this medication as the risk of liver damage increases. If severe rashes, hives, pustular rashes, or severe skin reactions occur, discontinue use immediately and inform a healthcare professional. This medication should not be used by anyone with hypersensitivity to acetaminophen or its components, patients with peptic ulcers, severe blood, liver, kidney, heart diseases, those with aspirin-induced asthma, individuals currently taking certain medications, or those who have consumed alcohol. Patients with liver or kidney dysfunction or a history thereof, elderly individuals, children, pregnant women, and breastfeeding mothers should use it cautiously, with regular monitoring if necessary. This drug can rarely cause a variety of adverse reactions such as decreased blood cell counts, increased liver enzyme levels, kidney dysfunction, and severe allergic reactions, so any unusual symptoms should prompt immediate consultation with a healthcare provider. There may be drug interactions, particularly if taken with probenecid, salicylamide, isoniazid, carbamazepine, phenytoin, and oral anticoagulants. It does not affect driving or machine operation, and should not be mixed with other drugs. Minimum doses should be used in children and elderly patients, with close attention to adverse reactions. In cases of infection, this medication may mask symptoms, so it should be taken in accordance with a physician's instructions along with appropriate antimicrobial agents. During pregnancy, the benefits and risks of this medication should be carefully assessed, adhering strictly to the recommended dosage and duration. Breastfeeding mothers may use this medication, but should consult with healthcare professionals if adverse reactions occur. Patients with severely impaired renal function should extend the dosing interval to at least 6 hours. In case of overdose, symptoms such as nausea, vomiting, loss of appetite, pallor, and lower abdominal pain may occur, and in severe cases, it can lead to liver cell destruction and coma, requiring immediate emergency treatment. This medication should not be stored at temperatures above 30 degrees Celsius, should not be refrigerated or frozen, and should be visually checked for discoloration or particulates before use. It is for single use only, and any unused solution should be discarded after use.

Serious side effects

Allergic reactions, shock, agranulocytosis, neutropenia, leukopenia, thrombocytopenia, coma, acute renal failure, Lyell's syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, thrombocytopenia, fulminant hepatitis, liver necrosis, liver failure, increased liver enzymes, angioedema, anaphylactic shock, anaphylaxis, hypersensitivity reactions requiring discontinuation of treatment, severe allergic reactions, severe skin reactions, severe

Mild side effects

• Fatigue
• low blood pressure
• increased liver transaminase levels
• neurological symptoms
• rash
• injection site reaction
• maculopapular rash
• pseudo-pemphigus reaction
• pustular rash
• nausea

This medication should be stored at room temperature between 1 and 30 degrees Celsius, and it is important to keep it in a well-closed container to prevent air exposure. This will help maintain the drug's effectiveness and prevent degradation.

Appearance

A clear, pale yellow transparent liquid filled in a colorless and transparent plastic infusion container.

Package unit

For injection - 100 milliliters/bag, For injection - 50 milliliters/bag