Supraamin 7.5%

Adult dosage

Generally, administer a single dose of 500 mL by infusion. The infusion rate is at least 180 minutes for a dose of 500 mL in adults. When administering through central venous access, mix 500 mL of this medication with dextrose solution, and continuously infuse over 24 hours. Adjust appropriately based on age, symptoms, and body weight.

This medication must be used as directed by a physician, and should not be taken or discontinued arbitrarily. It should not be administered to patients with severely impaired kidney function or high blood nitrogen levels. Patients with liver dysfunction or abnormalities in amino acid metabolism should also not use this medication. Administration should be avoided in patients with metabolic disorders involving nitrogen utilization issues, severe heart failure, or pulmonary edema. It is safer not to use this in patients with extremely low or no urine output (oliguria or anuria). Patients with high blood sodium or chloride ion concentrations, or alkalosis should be cautious, especially if this medication contains sodium or chloride. In patients with cardiac conduction disorders or severe muscle weakness, administration should be avoided if magnesium is included. This medication is contraindicated in patients who are excessively hydrated, those with a history of myocardial infarction, and should be avoided in similar cases. Use with caution in patients with severe acidosis, congestive or severe heart failure, abnormal sodium or potassium levels, and impaired kidney function. This medication contains sodium bisulfite, which may cause life-threatening allergic reactions or asthma attacks in patients allergic to sulfites or asthma. Caution is advised. During administration, rare side effects such as rash, nausea, vomiting, palpitations, or increased blood pressure may occur; if these symptoms occur, notify medical personnel immediately. Rapid bolus administration may cause metabolic acidosis, so control the rate of infusion. This medication can cause serious side effects such as chills, fever, headaches, shortness of breath, shock, bronchospasm, so immediate treatment is required if symptoms occur. If magnesium is included, peripheral blood vessels may dilate, leading to decreased blood pressure. This medication can induce various metabolic imbalances, including metabolic acidosis, hypophosphatemia, alkalosis, and hyperglycemia, necessitating regular testing. Patients with impaired liver or kidney function may experience elevated blood urea nitrogen (BUN) levels, and should be closely monitored as severe hepatic dysfunction may lead to coma. In massive administration, be cautious of electrolyte balance, especially when used in conjunction with electrolyte-containing solutions. This medication may induce chills or vomiting if infused rapidly, thus it must be administered slowly via intravenous injection. It is advisable to warm the solution to body temperature before use, and maintain strict aseptic conditions during preparation to minimize the risk of infection. Do not use cloudy or leftover solutions; after preparation, use it as soon as possible and within 24 hours if stored in a refrigerator. The safety of this medication during pregnancy has not been established; it should only be administered when the benefits outweigh the risks. When administering to children, maintain a lower concentration, and especially infants should have their blood ammonia levels checked frequently due to a deficiency in urea synthesis capacity, which increases the risk of hyperammonemia. Elderly patients may have diminished bodily functions, so it is safer to administer at a slower rate and a reduced dosage.

Serious side effects

Shortness of breath, respiratory arrest, shock, asthma attack, severe edema with elevated blood pressure

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• rapid heartbeat
• elevated blood pressure
• acidosis
• chills
• fever

This medication should be stored in a sealed container to prevent air or moisture ingress. It is best to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature, which will help to preserve the medication's efficacy.

Appearance

A colorless to pale yellow transparent injection in a plastic container for infusion.

Package unit

100 milliliters / pack, 250 milliliters / pack