Jext Pre-filled Pen 300 Micrograms (Epinephrine Tartrate)

Adult administration

In adults, it may be administered more than once for the treatment of allergic reactions. The initial dose should be injected immediately upon observation of anaphylaxis symptoms. The effective dosing range is generally 0.005 - 0.01 mg/kg, but higher doses may be required in some cases. If there are no clinical improvement symptoms or if they worsen, the second dose of this drug may be administered 5 to 15 minutes after the first dose. Therefore, it is always recommended that patients carry two of this medication.

Child administration

The general dosing for patients weighing 15 to 30 kg is 150 micrograms. A dose of 150 micrograms is not recommended for children weighing less than 15 kg (except in life-threatening situations or upon a doctor's recommendation).

This drug contains the ingredient sodium metabisulfite, which may rarely cause hypersensitivity reactions such as anaphylaxis or bronchospasm. Patients with a history of asthma should be particularly cautious when using this medication and must follow a doctor's instructions. The yellow cap should not be removed until the drug is ready for use, and injections should only be administered on the outer thigh. Injection into the buttocks is not allowed, and the black needle guard of the autoinjector must be pressed firmly against the skin or clothing to administer the injection immediately. Since an anaphylactic reaction may occur, it is necessary to request an ambulance and prepare for emergency treatment right after the first dose of this drug. Patients with low blood pressure, cardiovascular disease, hyperthyroidism, glaucoma, renal impairment, cor pulmonale, arrhythmia, benign prostatic hyperplasia, hypercalcemia, hypokalemia, diabetes, Parkinson's disease, elderly patients, pregnant women, and children under 15 kg must use this drug with extreme caution. This drug can cause various side effects such as increased heart rate, headache, dizziness, vomiting, muscle cramps, and circulatory disturbances, especially if injected incorrectly into the hands or feet. Patients prescribed this drug must thoroughly understand the usage and management methods and educate those around them, regularly checking the readiness for use. While this drug will not affect driving or operating machinery, caution must be taken after an anaphylactic reaction. This drug may interact with other medications, requiring caution when used with cardiac glycosides, diuretics, antiarrhythmics, tricyclic antidepressants, MAO inhibitors, certain antihistamines, insulin, and more. During pregnancy, this drug should only be administered when absolutely necessary, and its use should be avoided during labor. Safety in breastfeeding women has not been established, so it must be used cautiously. In cases of overdose, immediate emergency treatment is necessary for hypertension, cardiac arrhythmia, brain hemorrhage, myocardial damage, and renal impairment that may occur. This drug should be stored out of reach of children, at temperatures below 25 degrees Celsius, and should not be frozen. The drug should not be used if the contents are discolored or if there is sediment. Expired drugs should not be thrown away but should be disposed of properly by consulting a pharmacist.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reaction
• Brain hemorrhage caused by sudden hypertension
• Brain hemorrhage
• Ventricular arrhythmia
• Pulmonary edema
• Hypersensitivity, including anaphylaxis reaction and bronchospasm
• Peripheral ischemia* (hematomas, pain, bleeding, swelling, coldness, pallor, paresthesia, numbness at the injection site, if inadvertently injected into fingers and hands)
• Severe headache

Mild side effects

• Hyperglycemia
• hypokalemia
• metabolic acidosis
• tremors
• dizziness
• headache
• paresthesia
• numbness
• palpitations
• tachycardia

This drug must be stored in a sealed container to prevent exposure to air. Additionally, it is best to store the drug at a cool room temperature below 25 degrees Celsius.

Appearance

It is a pen-shaped pre-filled injection with a disposable needle containing a colorless, transparent solution.

Package unit

1.4mL single-use pre-filled pen x 1 piece / box 1.4mL single-use pre-filled pen x 2 pieces / box