Neomadol Injection 50mg (Tramadol Hydrochloride)

Adult administration

The dosage of tramadol hydrochloride is 50-100mg for intravenous or intramuscular injection, repeated as necessary every 4-5 hours. A maximum of 400mg can be administered in one day.

Caution is advised as overdose of this medication can lead to seizures. This drug should only be used when absolutely necessary in patients with a history of seizures or those at risk of seizures. Long-term use can lead to psychological and physical dependence; thus, it should only be used for a short period under strict supervision in patients with a history of substance abuse or dependence. Using this drug with alcohol or central nervous system depressants increases the risk of severe sedation, respiratory depression, and coma, so co-administration should be avoided or approached with caution. Patients with fast metabolism genetically may have elevated blood concentrations, increasing the risk of respiratory depression, necessitating dose adjustments and monitoring. It is advisable not to use this medication in children under 12 years or adolescents under 18 years with certain surgeries. This medication should not be administered to patients who have acute alcohol intoxication, severe respiratory depression, head trauma, or those on MAO inhibitors. Patients with severe liver or kidney impairment, pregnant women, and breastfeeding mothers are also recommended not to use this medication. Patients should avoid driving or operating dangerous machinery as drowsiness, dizziness, or nausea may occur during medication use. Additionally, discontinuing this drug abruptly can cause withdrawal symptoms; therefore, doses should be tapered off gradually under medical supervision. Due to many possible interactions with other medications that can enhance central nervous system depression, consultation with a physician or pharmacist is essential. During pregnancy or breastfeeding, this medication should not be used due to potential effects on the fetus or newborn. Elderly patients may require dose adjustments due to the potential for increased blood concentrations. In the event of an overdose, severe respiratory depression and seizures may occur, necessitating immediate emergency treatment; naloxone can be used as an antidote. This medication should be stored out of reach of children and kept in the original container to prevent misuse or degradation of quality.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions (shock, anaphylaxis), severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions (Stevens-Johnson syndrome), shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by coughing and fever, jaundice of the skin or eyes, general malaise, liver abnormalities, sudden and

Mild side effects

• Nausea
• vomiting
• drowsiness
• dizziness
• lightheadedness
• palpitations
• chills
• vasodilation
• hypotension
• arrhythmia

This medication should be stored in a sealed container to protect it from air exposure and kept at room temperature between 1 degrees to 30 degrees Celsius. Storing it this way will maintain the medication's effectiveness and prevent degradation.

Appearance

Colorless, transparent solution filled in a colorless transparent ampoule

Package unit

50 ampoules/box [(ampoule (1mL))]