Ultransemi Tablet

Adult dose

Children aged 12 years and older and adults: The dosage should be adjusted according to the severity of the patient's pain and therapeutic response. It is recommended to start with a dose of 4 tablets, with further doses spaced at least 6 hours apart, but not exceeding 16 tablets per day. Administer the lowest effective dose for as short a duration as possible. Do not prescribe this medication for longer than necessary; if long-term use is needed due to disease characteristics and severity, regular monitoring should be conducted to confirm whether this medication should continue to be taken. Elderly: Administer the usual adult dose. However, for elderly patients aged 75 years and older, the half-life of tramadol increases by 17% when taken orally, so ensure that doses are spaced at least 6 hours apart. Renal impairment: For moderate renal impairment (creatinine clearance of 10-30 mL/min), extend the dosing interval to 12 hours. It is not recommended for severe renal impairment (creatinine clearance of less than 10 mL/min). Tramadol is removed very slowly by hemodialysis and filtration, so it does not need to be readministered after dialysis to maintain analgesic effects. Hepatic impairment: For moderate hepatic impairment, consider extending the dosing interval with caution. Do not administer this medication in cases of severe hepatic impairment.

Child dose

Children aged 12 years and older and adults: The dosage should be adjusted according to the severity of the patient's pain and therapeutic response. It is recommended to start with a dose of 4 tablets, with further doses spaced at least 6 hours apart, but not exceeding 16 tablets per day.

This medication should be used with caution in individuals who consume more than three alcoholic beverages daily, as the risk of liver damage increases; consult a physician or pharmacist. This medication may rarely cause serious skin reactions; if skin rash or hypersensitivity occurs, discontinue use immediately. One of the components in this medication may provoke seizures, so patients with a history of seizures or increased seizure risk should use it carefully. Severe allergic reactions, such as anaphylaxis, may rarely occur during the use of this medication; notify medical personnel immediately if symptoms appear. In patients with acute and severe bronchial asthma, there is a high risk of respiratory depression; administration should occur in settings equipped for this. Severe sedation, respiratory depression, coma, or death may occur if this medication is combined with alcohol or certain central nervous system depressants; avoid combinations unless directed by a doctor. In patients with increased intracranial pressure or head injury, this medication may worsen symptoms due to respiratory depression; administration should be cautious. This medication can cause mental and physical dependence; therefore, consider adjusting the duration and dosage in long-term use. Patients with impaired liver function must consult a physician before using this medication, as its ingredients are metabolized by the liver, and dosage adjustments may be necessary. Some patients may have a high risk of severe respiratory depression based on genetic factors affecting metabolism, necessitating genetic testing or monitoring. This medication is contraindicated in children under 12 years and adolescents under 18 who have undergone certain surgeries; avoid use in these age groups. Patients with sleep apnea or at risk for hypoxia should carefully monitor for worsening symptoms during this medication's use, and dosage may need adjustment or discontinuation. This medication may cause hyponatremia; therefore, especially among the elderly or those with risk factors, regularly checking serum sodium levels is advisable. Do not administer this medication to specific patient groups, such as those with hypersensitivity to components of this medicine, severe respiratory depression, head injuries, or those taking MAO inhibitors. This medication may cause drowsiness or dizziness; use caution when driving or operating machinery. In the event of overdose, serious respiratory depression, seizures, or liver damage may occur; adhere to the prescribed dosage and seek medical attention immediately in case of overdose. Store this medication out of the reach of children and always consult a physician or pharmacist regarding potential interactions with other drugs.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pale skin, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucous membranes, shortness of breath or difficulty breathing, asthma attacks, abnormal respiratory features with coughing and fever, jaundice (yellowing of skin or eyes), extreme drowsiness, sudden and severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This medication should be stored in a tightly closed container to prevent exposure to air, and it is recommended to keep it at room temperature between 1°C and 30°C. This storage will help maintain its efficacy and prevent degradation.

Appearance

Pale yellow, rectangular film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle