Rabitra Tablet

Adult dose

Typically, the medication is orally administered as 2 tablets twice a day, regardless of meals, in the morning and before bedtime. 1) For gastric and duodenal ulcers: Administer 2 tablets twice a day or 4 tablets once a day before bedtime. In particular, for duodenal ulcer patients, taking 4 tablets twice a day in the morning and before bedtime can achieve higher treatment rates. This combination therapy also has the same dosage to prevent ulcers or for the long-term use of non-steroidal anti-inflammatory drugs. Generally, conditions arising from the use of non-steroidal anti-inflammatory drugs typically heal within 4-8 weeks, but healing times may vary by patient. For recurrent ulcer patients who showed excellent results with the short-term therapy, a maintenance dose of 2 tablets once daily at bedtime is recommended. 2) For gastroesophageal reflux disease: During 8 weeks, 2 tablets twice daily or 4 tablets once daily before bedtime are administered. However, in severe cases of gastroesophageal reflux disease, the dose may be increased to 4 tablets four times daily. 3) For Zollinger-Ellison syndrome: Begin treatment with 2 tablets three times a day as an initial dose, which may be increased as necessary. In severe cases, as directed by a physician, daily doses of ranitidine may be increased up to 6 g. 4) For peptic ulcers, acute stress ulcers, and upper gastrointestinal bleeding due to acute mucosal lesions: When oral administration is possible, switch from injection to oral dosing with 2 tablets twice a day. 5) For pre-anesthetic medication (to prevent Mendelson syndrome): 2 tablets are administered 2 hours before the induction of anesthesia. It is also good practice to administer 2 tablets the night before surgery.

This medication should not be used by patients undergoing dialysis or patients with kidney function issues. Patients who have experienced allergic reactions to this medication or its components, those with a history of acute porphyria, patients who have undergone upper gastrointestinal surgery, pregnant women or those who may become pregnant, premature infants and newborns, and patients on potassium-restricted diets should also refrain from taking this medication. Patients with impaired liver function or a history of drug allergies, the elderly, patients with a history of kidney disease, and patients taking non-steroidal anti-inflammatory drugs should use this medication with caution, particularly since it can mask gastric cancer symptoms. Therefore, patients with gastric ulcers or middle-aged patients who present new dyspeptic symptoms should have malignancy ruled out prior to treatment. Patients with Helicobacter pylori infection in gastric or duodenal ulcers should receive concomitant treatment to eradicate the bacteria, and special caution is needed for patients in critical care, those with hypophosphatemia, and patients with swallowing difficulties due to the possible risk of complications from this medication. Rarely, anaphylaxis or hypersensitivity reactions such as skin rashes, hives, or angioedema may occur, so if symptoms develop, administration should be stopped immediately and medical advice should be sought. Blood-related abnormalities such as reversible leukopenia and thrombocytopenia have been reported rarely, and symptoms such as liver dysfunction, arrhythmia, gastrointestinal symptoms, neuropsychiatric disturbances, musculoskeletal pain, and skin rashes may also occur; immediate reporting of unusual symptoms is necessary. Long-term use is not recommended and regular monitoring of blood, liver, and kidney function is required during treatment. Dizziness or drowsiness may occur during the use of this medication, so it is advisable to avoid driving or operating hazardous machinery. Moreover, this medication can interact with other drugs, so it is essential to inform medical personnel if taking other medications, particularly since caution is needed in conjunction with certain antibiotics or anticoagulants. It is safest for pregnant or breastfeeding women to avoid this medication, as safety and efficacy in pediatrics have not been established, and use is not recommended. In case of overdose, emergency measures such as vomiting or gastric lavage may be needed. Since this medication reduces gastric acid secretion, it may promote bacterial growth in the stomach, so regular eye examinations may be necessary with long-term use.

Serious side effects

Hives, severe swelling (angioedema), tightness in the chest, difficulty breathing, shock (anaphylaxis), severe allergic reactions, severe skin reactions, vasculitis, liver abnormalities (jaundice), liver dysfunction, dizziness, drowsiness, consciousness disturbances, seizures, myoclonic jerks, neurologic symptoms (seizures, altered consciousness), agranulocytosis, pancytopenia, aplastic anemia, immune hemolytic anemia, acute convulsions

Mild side effects

• Skin rash
• angioedema
• fever
• bronchospasm
• hypotension
• chest pain
• nausea
• vomiting
• constipation
• diarrhea

This medication should be stored in a tightly sealed container to prevent air and moisture entry and should be kept at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the medication's efficacy and prevents degradation.

Appearance

Round white film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle