Lipidem Injection

Adult administration

The dosage for adults should be adjusted appropriately according to patient needs. The daily dose is administered at a rate of 0.7-1.5g/kg as fat per body weight. The maximum daily dose is 2.0g/kg as fat per body weight. The administration rate should be at the lowest possible rate, up to a maximum of 0.15g fat/kg/hour (0.75mL/kg/hour). For the first 15 minutes, administer at 50% of the maximum administration rate.

Child administration

Children are administered gradually at a rate of 0.5-1.0g/kg as fat per body weight per day, to monitor increases in plasma triglyceride levels and prevent hyperlipidemia. Premature infants, newborns, infants.

This medication should be used cautiously in premature or low-birth-weight infants, as it may increase plasma free fatty acid levels. It should not be administered to patients with certain conditions such as severe hyperlipidemia, blood clotting disorders, severely impaired liver or kidney function, acute myocardial infarction or stroke. Patients with allergies to eggs, fish, soy protein, soybean oil, peanuts, etc., should also avoid it. Careful administration is required for patients with lipid metabolism disorders such as hyperlipoproteinemia or diabetic dyslipidemia, and pancreatitis. Rare side effects may include abnormalities in blood coagulation, hypersensitivity reactions, hyperlipidemia, drowsiness, blood pressure changes, respiratory distress, nausea, headaches, and others. If adverse reactions occur or if plasma triglyceride levels rise above a certain threshold, discontinuation or dosage adjustment is necessary. This medication should be part of a complete intravenous nutrition regimen including amino acids and glucose, as its standalone use may cause metabolic acidosis. Regular monitoring of serum triglycerides, blood glucose, electrolytes, fluid balance, and liver function is required during administration. Caution is needed for overdose as fatty overload syndrome may occur; in such cases, administration should be stopped immediately and appropriate treatment provided. The safety of this medication during pregnancy or lactation has not been sufficiently verified, thus it should be used with caution. This medication does not affect driving or operating machinery. Prior to administration, check that the medication is homogeneous and not deteriorated; store in a sealed container out of reach of children in a cool place. Use immediately after opening, and dispose of any remaining medication, avoiding freezing.

Serious side effects

• Urticaria
• severe edema
• chest tightness
• difficulty breathing
• severe rash with fever
• blisters
• skin peeling
• pain in oral/ocular mucosa
• respiratory distress
• cyanosis

Mild side effects

• Hypercoagulation
• hyperlipidemia
• hyperglycemia
• metabolic acidosis
• ketoacidosis
• drowsiness
• hypertension or hypotension
• nausea
• vomiting
• headache

This medication should be stored in a sealed container to prevent air ingress and care should be taken to avoid freezing. A storage temperature of between 1 degree and 25 degrees in a cool place is appropriate.

Appearance

A white, opaque, uniform emulsion in a colorless, transparent glass vial.

Package unit

Vial - 100 milliliters/vial, Vial - 250 milliliters/vial, Vial - 500 milliliters/vial