Orphen Tablets

Adult dose

For children aged 12 and older and adults: Dosage should be adjusted according to the patient's level of pain and therapeutic response. A starting dose of 2 tablets is recommended, and the interval between doses should be at least 6 hours, ensuring that a maximum of 8 tablets is not exceeded in one day. The effective minimum dose should be administered for as short a duration as possible. Do not take this medication for longer than necessary, and if long-term use is needed due to the nature and severity of the disease, regular monitoring should be conducted to verify the continuation of this medication. Elderly Administer the usual adult dosage. However, for the elderly over 75 years of age, the elimination half-life of tramadol is increased by 17% when taken orally, so doses should be administered at least 6 hours apart. Patients with renal impairment For moderate renal impairment patients (creatinine clearance of 10-30 mL/min), extend the dosing interval to 12 hours. For severe renal impairment patients (creatinine clearance less than 10 mL/min), use is not recommended. Tramadol is removed very slowly during hemodialysis, so there is no need to re-administer this medication after dialysis for pain relief. Patients with liver impairment Use caution in extending the dosing interval for patients with moderate liver impairment. The medication should not be administered to patients with severe liver impairment.

Child dose

As it pertains to children aged 12 and older and adults, no separate pediatric dosage is specified.

This medication can put a strain on the liver, so individuals who regularly consume more than three glasses of alcohol per day should consult a doctor or pharmacist before taking it. If a rash or allergic reaction occurs during the use of this medication, discontinue use immediately and consult a healthcare professional. There is a risk of seizures, so patients with a history of seizures or seizure risk factors should use this medication cautiously. This medication can rarely cause serious allergic reactions, so if symptoms such as difficulty breathing or hives appear while taking it, seek medical attention immediately. Patients with respiratory problems, particularly those with asthma, should take special care when using this medication due to the risk of respiratory suppression. Taking this medication with alcohol or central nervous system depressants can cause severe drowsiness, respiratory suppression, or coma, so concurrent use should be avoided. Patients with head injuries or increased intracranial pressure should exercise caution as symptoms may worsen while taking this medication. Long-term use may lead to physical and psychological dependence, so individuals should follow their doctor's instructions and not discontinue use abruptly. Patients with impaired liver function should consult a doctor before taking this medication and must be careful not to exceed the recommended dosage. Certain patients with rapid genetic metabolism may experience excessive effects of this medication, leading to serious side effects such as respiratory suppression, so caution is required. This medication should not be administered to children under 12 years old or to children after certain surgeries, and teenagers aged 12 to 18 should avoid taking it if risk factors are present. Patients with sleep apnea or hypoxemia should monitor for symptom deterioration while taking this medication. This medication may cause hyponatremia, so it is advisable for elderly individuals or those with risk factors to periodically check their serum sodium levels. Patients who are hypersensitive to any component of this medication or are in severe respiratory suppression, have head injuries, or are taking MAO inhibitors should not take this medication. Pregnant or breastfeeding women should consult a doctor before taking this medication as it may affect the fetus or neonate. Drowsiness or dizziness may occur, so caution is advised when driving or operating machinery. In the case of an overdose, serious respiratory suppression, seizures, liver damage, etc., may occur, so the prescribed dosage should be followed meticulously, and if overdose is suspected, emergency treatment must be sought immediately. Care should be taken not to use this medication concurrently with other analgesics or medications containing acetaminophen, and patients must inform their healthcare provider of all medications they are taking due to potential drug interactions. Store this medication in a safe place out of the reach of children to prevent accidental ingestion.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

The storage method for this medication differs between domestic and export use. Domestic medications should be stored in a sealed container at room temperature between 1 degree and 30 degrees Celsius. Export medications should be stored in a sealed container at a cool room temperature below 25 degrees Celsius. Storing them this way helps maintain the drug's effectiveness and prevents degradation.

Appearance

Pale yellow oblong film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle